Microtrial Methods for Translating Gene-environment Dynamics into Preventive Interventions

Microtrial Methods for Translating Gene-environment Dynamics into Preventive Interventions Genetically informed research on behavioral outcomes holds substantial promise for guiding efforts to enhance the efficacy and effectiveness of preventive interventions, but it also poses considerable challenges given the complexities of the dynamic interplay between genes and environment. This paper introduces a relatively uncommon research design, called microtrials, to provide a means of translating basic research findings into prevention trials, particularly through introducing genetic effects into prevention models. Microtrials are defined as randomized experiments testing the effects of relatively brief and focused environmental manipulations designed to suppress specific risk mechanisms or enhance specific protective mechanisms, but not to bring about full treatment or prevention effects in distal outcomes. Microtrial methods are described in detail, with discussion of their unique advantages for translating this knowledge base into prevention research. We end by raising several issues to consider when constructing genetically sensitive microtrials. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Prevention Science Springer Journals

Microtrial Methods for Translating Gene-environment Dynamics into Preventive Interventions

Loading next page...
Springer US
Copyright © 2010 by Society for Prevention Research
Medicine & Public Health; Public Health; Health Psychology; Child and School Psychology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial