Microsurgical repair of nerve lesions with nerve grafts: the effect of nerve growth factor 7S

Microsurgical repair of nerve lesions with nerve grafts: the effect of nerve growth factor 7S This study investigated the effect of local administration of nerve growth factor 7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through nerve grafts. Sixty male Wistar rats were randomized into two groups (n=30). A defect 12 mm long in the right sciatic nerve was created and repaired with a nerve autograft. NGF-7S (group A) or normal saline (group B-control) was locally administered daily during the first 3 weeks. For this purpose a subcutaneously implanted reservoir connected to a silicone tube was used. Electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10 and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n=6 each). Data analysis showed that: (a) the evoked muscle action potential and (b) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through nerve grafts. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals
Loading next page...
 
/lp/springer_journal/microsurgical-repair-of-nerve-lesions-with-nerve-grafts-the-effect-of-l7t2Z0urjw
Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-002-0386-4
Publisher site
See Article on Publisher Site

Abstract

This study investigated the effect of local administration of nerve growth factor 7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through nerve grafts. Sixty male Wistar rats were randomized into two groups (n=30). A defect 12 mm long in the right sciatic nerve was created and repaired with a nerve autograft. NGF-7S (group A) or normal saline (group B-control) was locally administered daily during the first 3 weeks. For this purpose a subcutaneously implanted reservoir connected to a silicone tube was used. Electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10 and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n=6 each). Data analysis showed that: (a) the evoked muscle action potential and (b) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through nerve grafts.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Sep 12, 2002

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off