Clin Transl Oncol (2017) 19:1133–1140 DOI 10.1007/s12094-017-1650-1 RESEARCH AR TIC L E MicroRNA-9 promotes the proliferation, migration, and invasion of breast cancer cells via down-regulating FOXO1 1 1 2 2 3 • • • • D.-Z. Liu B. Chang X.-D. Li Q.-H. Zhang Y.-H. Zou Received: 27 December 2016 / Accepted: 13 March 2017 / Published online: 10 April 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract breast epithelial cells (both P \ 0.05). FOXO1 mRNA and Purpose The objective of the study was to investigate the protein expressions were substantially down-regulated in role of microRNA-9 (miR-9) targeting forkhead box O1 breast cancer tissues and breast cancer cell lines when (FOXO1) in the proliferation, migration, and invasion of compared with normal breast tissues and normal breast breast cancer cells. epithelial cells (both P \ 0.05). There can be a negative Methods Quantitative real-time polymerase chain reaction correlation between miR-9 and FOXO1 mRNA in breast (qRT-PCR) was employed to determine the expressions of cancer. Luciferase reporter gene assay indicated that miR-9 miR-9 and FOXO1 mRNA in breast cancer tissues, normal can down-regulate FOXO1 expression at a post-transcrip- breast tissues, breast cancer cell lines,
Clinical and Translational Oncology – Springer Journals
Published: Apr 10, 2017
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