J Neurooncol (2017) 134:241–242 DOI 10.1007/s11060-017-2500-2 LETTER TO THE EDITOR MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project 1 2 1 Mo Yang · Harrison X. Bai · Li Yang Received: 28 November 2016 / Accepted: 20 May 2017 / Published online: 25 May 2017 © Springer Science+Business Media New York 2017 To the Editor, miRNA-21 expression, age and KPS score were treated as continuous variables, while tumor grade and IDH1/2 We read with great interest a recent study by Li et al. on the mutant status were treated as ordinal variables. Statistical prognostic value of microRNA-21 in gliomas . By per- analysis was performed using SPSS version 22 (Interna- forming a meta-analysis of relevant published literature, the tional Business Machines Corporation, Armonk, NY). authors found that high miRNA-21 expression was associ- We included 244 patients in our cohort, among which ated with lower overall survival (OS) in both gliomas and 105 were grade II tumors and 139 were grade III tumors. GBM. First, each miRNA-21 expression was factored into a mul- We conducted a similar analysis using lower-grade tivariable Cox proportional hazards model with age, KPS, glioma (LGG) dataset from the Cancer Genome Atlas IDH mutant status and tumor
Journal of Neuro-Oncology – Springer Journals
Published: May 25, 2017
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