MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project

MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas... J Neurooncol (2017) 134:241–242 DOI 10.1007/s11060-017-2500-2 LETTER TO THE EDITOR MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project 1 2 1 Mo Yang  · Harrison X. Bai  · Li Yang   Received: 28 November 2016 / Accepted: 20 May 2017 / Published online: 25 May 2017 © Springer Science+Business Media New York 2017 To the Editor, miRNA-21 expression, age and KPS score were treated as continuous variables, while tumor grade and IDH1/2 We read with great interest a recent study by Li et al. on the mutant status were treated as ordinal variables. Statistical prognostic value of microRNA-21 in gliomas [1]. By per- analysis was performed using SPSS version 22 (Interna- forming a meta-analysis of relevant published literature, the tional Business Machines Corporation, Armonk, NY). authors found that high miRNA-21 expression was associ- We included 244 patients in our cohort, among which ated with lower overall survival (OS) in both gliomas and 105 were grade II tumors and 139 were grade III tumors. GBM. First, each miRNA-21 expression was factored into a mul- We conducted a similar analysis using lower-grade tivariable Cox proportional hazards model with age, KPS, glioma (LGG) dataset from the Cancer Genome Atlas IDH mutant status and tumor http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuro-Oncology Springer Journals

MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Oncology; Neurology
ISSN
0167-594X
eISSN
1573-7373
D.O.I.
10.1007/s11060-017-2500-2
Publisher site
See Article on Publisher Site

Abstract

J Neurooncol (2017) 134:241–242 DOI 10.1007/s11060-017-2500-2 LETTER TO THE EDITOR MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project 1 2 1 Mo Yang  · Harrison X. Bai  · Li Yang   Received: 28 November 2016 / Accepted: 20 May 2017 / Published online: 25 May 2017 © Springer Science+Business Media New York 2017 To the Editor, miRNA-21 expression, age and KPS score were treated as continuous variables, while tumor grade and IDH1/2 We read with great interest a recent study by Li et al. on the mutant status were treated as ordinal variables. Statistical prognostic value of microRNA-21 in gliomas [1]. By per- analysis was performed using SPSS version 22 (Interna- forming a meta-analysis of relevant published literature, the tional Business Machines Corporation, Armonk, NY). authors found that high miRNA-21 expression was associ- We included 244 patients in our cohort, among which ated with lower overall survival (OS) in both gliomas and 105 were grade II tumors and 139 were grade III tumors. GBM. First, each miRNA-21 expression was factored into a mul- We conducted a similar analysis using lower-grade tivariable Cox proportional hazards model with age, KPS, glioma (LGG) dataset from the Cancer Genome Atlas IDH mutant status and tumor

Journal

Journal of Neuro-OncologySpringer Journals

Published: May 25, 2017

References

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