Micronuclei and Ageing in a Sample of Yugoslavian Population

Micronuclei and Ageing in a Sample of Yugoslavian Population Objective: instability in the organization and expression of the genetic material has been hypothesized as the basic mechanism of ageing. Aim of this study was to quantify the effect of ageing on spontaneous micronuclei (MN) frequency in peripheral blood lymphocytes. Method: analysis of Yugoslavian population sample (164 tested individuals, age 0–62 years) has performed by application of cytokinesis-block technique (CB). Results: there was an increase of MN frequency with age, from newborns to 40-year-old persons. The total average of MN frequency per 1000 analyzed binuclear cells amounts to 8.03 ± 0.42, with variation from 0 to 26 MNs. In a sample of 29 newborns the recorded average MN frequency was 6.91 ± 0.81, while among 69 persons 25–39 years old, the MN frequency was 9.16 ± 1.00. The lowest average MN frequency, however, was noted in the sample of 34 tested individuals 40 to 62 years of age. Conclusion: an increase with age in MN frequency has been observed in samples of studied individuals from newborns to 40-year-old persons. A decrease of MN frequency in older groups could be explained by a gradual decrease of proliferative cell capacities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Micronuclei and Ageing in a Sample of Yugoslavian Population

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1014342312959
Publisher site
See Article on Publisher Site

Abstract

Objective: instability in the organization and expression of the genetic material has been hypothesized as the basic mechanism of ageing. Aim of this study was to quantify the effect of ageing on spontaneous micronuclei (MN) frequency in peripheral blood lymphocytes. Method: analysis of Yugoslavian population sample (164 tested individuals, age 0–62 years) has performed by application of cytokinesis-block technique (CB). Results: there was an increase of MN frequency with age, from newborns to 40-year-old persons. The total average of MN frequency per 1000 analyzed binuclear cells amounts to 8.03 ± 0.42, with variation from 0 to 26 MNs. In a sample of 29 newborns the recorded average MN frequency was 6.91 ± 0.81, while among 69 persons 25–39 years old, the MN frequency was 9.16 ± 1.00. The lowest average MN frequency, however, was noted in the sample of 34 tested individuals 40 to 62 years of age. Conclusion: an increase with age in MN frequency has been observed in samples of studied individuals from newborns to 40-year-old persons. A decrease of MN frequency in older groups could be explained by a gradual decrease of proliferative cell capacities.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 13, 2004

References

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