Calcified Tissue International (2018) 102:385–386 https://doi.org/10.1007/s00223-018-0391-7 EDITORIAL René Rizzoli Received: 7 January 2018 / Accepted: 11 January 2018 / Published online: 9 February 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 The largest number of cells (10 14) in the human body are of the Journal, the associations between bone health and GM located within the intestinal tract lumen. This number is are reviewed and discussed. much higher than the number of cells in any human body In a well-detailed paper, Schwarzer and Strigini et al. parenchyma. The estimated number of different species are reviewing the role of GM in growth, through experi- varies between 1000 and 5000 comprising gram-positive mental models including Drosophila, worms, crustacea, and gram-negative bacteria, Archaea, Eukarya, as well as Zebrafish, chicken, and mice [9 ]. One factor implicated in viruses. These organisms are collectively called the gut bone growth is insulin-like growth factor I (IGF-I). GM microbiota (GM). They mostly refer to the large intestine is able to modulate and stimulate IGF-I synthesis by the content, but all parts of the gastrointestinal tract are colo- host in a dynamic interaction, as summarized by Yan and nized with an increasing density from the duodenum
Calcified Tissue International – Springer Journals
Published: Feb 9, 2018
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