Metronidazole

Metronidazole Reactions 1680, p230 - 2 Dec 2017 Acute cerebellar ataxia: case report A 56-year-old man developed acute cerebellar ataxia during treatment with metronidazole [duration of treatment to reaction onset not stated]. The man presented with complaint of progressive imbalance while walking. His history was significant for swaying side to side, vitiligo and megaloblastic anaemia due to vitamin B12 deficiency. He was receiving regular vitamin B12 injections. Investigations revealed gait and truncal ataxia. MRI results revealed bilaterally symmetrical T2 and FLAIR hyperintensity in dorsal pons and dentate nucleus. Further analysis of his history revealed that, he was on oral metronidazole 400mg three times/day from the past two weeks for loose motions. Consequently, a diagnosis of metronidazole induced acute cerebellar ataxia was considered based on his test results. The man was hospitalised, and metronidazole was discontinued. Subsequently, his symptoms resolved within seven days. During follow up examination at one month, he was asymptomatic. Author comment: "A diagnosis of metronidazole-induced acute cerebellar ataxia was made in the presence of the clinical features on neuroimaging findings and temporal relationship with metronidazole use." Duberkar D, et al. 56-Year-Old Male With Acute-Onset Ataxia After Metronidazole Use and a Typical MRI Appearance. Movement Disorders Clinical Practice 2: 422-423, No. 4, Dec 2015. Available from: URL: http:// doi.org/10.1002/mdc3.12186 - India 803284579 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Metronidazole

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39161-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p230 - 2 Dec 2017 Acute cerebellar ataxia: case report A 56-year-old man developed acute cerebellar ataxia during treatment with metronidazole [duration of treatment to reaction onset not stated]. The man presented with complaint of progressive imbalance while walking. His history was significant for swaying side to side, vitiligo and megaloblastic anaemia due to vitamin B12 deficiency. He was receiving regular vitamin B12 injections. Investigations revealed gait and truncal ataxia. MRI results revealed bilaterally symmetrical T2 and FLAIR hyperintensity in dorsal pons and dentate nucleus. Further analysis of his history revealed that, he was on oral metronidazole 400mg three times/day from the past two weeks for loose motions. Consequently, a diagnosis of metronidazole induced acute cerebellar ataxia was considered based on his test results. The man was hospitalised, and metronidazole was discontinued. Subsequently, his symptoms resolved within seven days. During follow up examination at one month, he was asymptomatic. Author comment: "A diagnosis of metronidazole-induced acute cerebellar ataxia was made in the presence of the clinical features on neuroimaging findings and temporal relationship with metronidazole use." Duberkar D, et al. 56-Year-Old Male With Acute-Onset Ataxia After Metronidazole Use and a Typical MRI Appearance. Movement Disorders Clinical Practice 2: 422-423, No. 4, Dec 2015. Available from: URL: http:// doi.org/10.1002/mdc3.12186 - India 803284579 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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