Metronidazole

Metronidazole Reactions 1704, p247 - 2 Jun 2018 Drug-induced encephalopathy: case report A 65-year-old man developed drug-induced encephalopathy while receiving metronidazole [dosage not stated] for relapse of perianal abscess. The man, who had rectal cancer and recurrent perianal abscess, was receiving treatment with oral metronidazole and ceftibuten since December 2016. One month later, he developed ataxia and dizziness. Subsequently, he was diagnosed with metronidazole-induced encephalopathy based on the clinical symptoms and findings of imaging studies. Thereafter, the man’s metronidazole treatment was stopped and symptoms of encephalopathy improved. He was then ineffectively treated for the perianal abscess with other unspecified antibiotics. Subsequently, he was treated with rectal metronidazole suppository at an initial dose of 250mg every night for few days. Thereafter, the metronidazole dose was uptitrated to 500mg every 6 hours. The perianal abscess discharge improved without any symptoms of encephalopathy. Author comment: "Metronidazole-induced encephalopathy was diagnosed by clinical symptoms and image study, and reversibly improved symptoms after metronidazole cessation." Lu H-E, et al. Use suppository form of metronidazole to avoid encephalopathy side-effect. International Journal of Antimicrobial Agents 50 (Suppl. 2): S106 abstr. PS 098, Nov 2017. Available from: URL: https://doi.org/10.1016/ S0924-8579(17)30423-5 [abstract] - Taiwan 803323302 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Metronidazole

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46890-z
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p247 - 2 Jun 2018 Drug-induced encephalopathy: case report A 65-year-old man developed drug-induced encephalopathy while receiving metronidazole [dosage not stated] for relapse of perianal abscess. The man, who had rectal cancer and recurrent perianal abscess, was receiving treatment with oral metronidazole and ceftibuten since December 2016. One month later, he developed ataxia and dizziness. Subsequently, he was diagnosed with metronidazole-induced encephalopathy based on the clinical symptoms and findings of imaging studies. Thereafter, the man’s metronidazole treatment was stopped and symptoms of encephalopathy improved. He was then ineffectively treated for the perianal abscess with other unspecified antibiotics. Subsequently, he was treated with rectal metronidazole suppository at an initial dose of 250mg every night for few days. Thereafter, the metronidazole dose was uptitrated to 500mg every 6 hours. The perianal abscess discharge improved without any symptoms of encephalopathy. Author comment: "Metronidazole-induced encephalopathy was diagnosed by clinical symptoms and image study, and reversibly improved symptoms after metronidazole cessation." Lu H-E, et al. Use suppository form of metronidazole to avoid encephalopathy side-effect. International Journal of Antimicrobial Agents 50 (Suppl. 2): S106 abstr. PS 098, Nov 2017. Available from: URL: https://doi.org/10.1016/ S0924-8579(17)30423-5 [abstract] - Taiwan 803323302 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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