Reactions 1704, p247 - 2 Jun 2018 Drug-induced encephalopathy: case report A 65-year-old man developed drug-induced encephalopathy while receiving metronidazole [dosage not stated] for relapse of perianal abscess. The man, who had rectal cancer and recurrent perianal abscess, was receiving treatment with oral metronidazole and ceftibuten since December 2016. One month later, he developed ataxia and dizziness. Subsequently, he was diagnosed with metronidazole-induced encephalopathy based on the clinical symptoms and findings of imaging studies. Thereafter, the man’s metronidazole treatment was stopped and symptoms of encephalopathy improved. He was then ineffectively treated for the perianal abscess with other unspecified antibiotics. Subsequently, he was treated with rectal metronidazole suppository at an initial dose of 250mg every night for few days. Thereafter, the metronidazole dose was uptitrated to 500mg every 6 hours. The perianal abscess discharge improved without any symptoms of encephalopathy. Author comment: "Metronidazole-induced encephalopathy was diagnosed by clinical symptoms and image study, and reversibly improved symptoms after metronidazole cessation." Lu H-E, et al. Use suppository form of metronidazole to avoid encephalopathy side-effect. International Journal of Antimicrobial Agents 50 (Suppl. 2): S106 abstr. PS 098, Nov 2017. Available from: URL: https://doi.org/10.1016/ S0924-8579(17)30423-5 [abstract] - Taiwan 803323302 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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