Metoclopramide/prochlorperazine

Metoclopramide/prochlorperazine Reactions 1704, p246 - 2 Jun 2018 Drug-induced Parkinsonism: case report A 72-year-old woman developed drug-induced Parkinsonism (DIP) following treatment with metoclopramide and prochlorperazine [dosages and routes not stated]. The woman with high-grade mullerian adenocarcinoma was admitted for intractable nausea, vomiting and rapid decline in nd functional status, after the 2 cycle of chemotherapy. Her anti- emetics included scheduled prochlorperazine and ondansetron, with as needed metoclopramide and lorazepam. She reported "contractures" that made participating in therapy difficult. Her physical examination showed flat affect, slowed speech and upper extremity rigidity with resting tremor. In view of her antiemetic regimen and physical examination findings, DIP was suspected. After neurology consultation, she was diagnosed with DIP. Consequently, metoclopramide and prochlorperazine were stopped. The woman was advised to avoid other dopamine- depleting drugs. Her nausea was controlled with ondansetron and lorazepam. She was discharged to a nursing facility. She improved enough to receive more chemotherapy. Author comment: "Neurology agreed with likely diagnosis of Drug- Induced Parkinsonism and recommended stopping metoclopramide and prochlorperazine and avoiding other dopamine-depleting drugs." Thomas AC, et al. Drug induced parkinsonism impacting functional status and treatment options in an elderly female patient. Journal of the American Geriatrics Society 66 (Suppl. 2): S15, Apr 2018. Available from: URL: http:// doi.org/10.1111/jgs.15376 [abstract] - USA 803323543 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Metoclopramide/prochlorperazine

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46889-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p246 - 2 Jun 2018 Drug-induced Parkinsonism: case report A 72-year-old woman developed drug-induced Parkinsonism (DIP) following treatment with metoclopramide and prochlorperazine [dosages and routes not stated]. The woman with high-grade mullerian adenocarcinoma was admitted for intractable nausea, vomiting and rapid decline in nd functional status, after the 2 cycle of chemotherapy. Her anti- emetics included scheduled prochlorperazine and ondansetron, with as needed metoclopramide and lorazepam. She reported "contractures" that made participating in therapy difficult. Her physical examination showed flat affect, slowed speech and upper extremity rigidity with resting tremor. In view of her antiemetic regimen and physical examination findings, DIP was suspected. After neurology consultation, she was diagnosed with DIP. Consequently, metoclopramide and prochlorperazine were stopped. The woman was advised to avoid other dopamine- depleting drugs. Her nausea was controlled with ondansetron and lorazepam. She was discharged to a nursing facility. She improved enough to receive more chemotherapy. Author comment: "Neurology agreed with likely diagnosis of Drug- Induced Parkinsonism and recommended stopping metoclopramide and prochlorperazine and avoiding other dopamine-depleting drugs." Thomas AC, et al. Drug induced parkinsonism impacting functional status and treatment options in an elderly female patient. Journal of the American Geriatrics Society 66 (Suppl. 2): S15, Apr 2018. Available from: URL: http:// doi.org/10.1111/jgs.15376 [abstract] - USA 803323543 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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