Methylthioninium chloride

Methylthioninium chloride Reactions 1680, p229 - 2 Dec 2017 Limited pneumothorax, blue urine and cough with expectoration of blue sputum: 8 case reports In a study, eight patients [ages and sexes not stated] were described, who developed limited pneumothorax (4 patients), blue urine (3 patients) and cough with expectoration of blue sputum (3 patients) during injection of methylthioninium chloride [methylene blue; dosage not stated]. All eight patients had nodules in the lungs. All patients underwent CT-guided labelling of the nodules with injection of methylthioninium chloride for video-assisted thoracic surgery (VATS). Subsequently, all eight patients developed complications, which included limited pneumothorax in four patients, blue urine in three patients and coughing with blue sputum expectoration for a few minutes in three patients [times to reactions onsets not stated; not all outcomes stated]. Author comment: "Herein we discuss our experience with CT-guided [methylthioninium chloride] labelling" "We did not observe any major complication. Three of the patients had small pneumothorax that did not require chest tube drainage. Three of the patients suffered from coughing with blue sputum expectoration for a few minutes after the [labelling], without any clinical significance. Also, two patients’ urine [colour] changed to blue for one day" Findik G, et al. Computed Tomography-Guided Methylene Blue Labeling Prior to Thoracoscopic Resection of Small Deeply Placed Pulmonary NodulesDo We Really Need Palpation?. Thoracic and Cardiovascular Surgeon 65: 387-391, No. 5, Aug 2017. Available from: URL: http://doi.org/10.1055/s-0036-1598019 - Turkey 803285351 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Methylthioninium chloride

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39160-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p229 - 2 Dec 2017 Limited pneumothorax, blue urine and cough with expectoration of blue sputum: 8 case reports In a study, eight patients [ages and sexes not stated] were described, who developed limited pneumothorax (4 patients), blue urine (3 patients) and cough with expectoration of blue sputum (3 patients) during injection of methylthioninium chloride [methylene blue; dosage not stated]. All eight patients had nodules in the lungs. All patients underwent CT-guided labelling of the nodules with injection of methylthioninium chloride for video-assisted thoracic surgery (VATS). Subsequently, all eight patients developed complications, which included limited pneumothorax in four patients, blue urine in three patients and coughing with blue sputum expectoration for a few minutes in three patients [times to reactions onsets not stated; not all outcomes stated]. Author comment: "Herein we discuss our experience with CT-guided [methylthioninium chloride] labelling" "We did not observe any major complication. Three of the patients had small pneumothorax that did not require chest tube drainage. Three of the patients suffered from coughing with blue sputum expectoration for a few minutes after the [labelling], without any clinical significance. Also, two patients’ urine [colour] changed to blue for one day" Findik G, et al. Computed Tomography-Guided Methylene Blue Labeling Prior to Thoracoscopic Resection of Small Deeply Placed Pulmonary NodulesDo We Really Need Palpation?. Thoracic and Cardiovascular Surgeon 65: 387-391, No. 5, Aug 2017. Available from: URL: http://doi.org/10.1055/s-0036-1598019 - Turkey 803285351 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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