Methylprednisolone/prednisone Reactions 1680, p228 - 2 Dec 2017 Myopathy and hyperglycaemia: case report A 64-year-old man developed hyperglycaemia and myopathy during treatment with methylprednisolone and prednisone, respectively [not all durations of treatments to reactions onsets stated]. The man, who was diagnosed with eosinophilic granulomatosis with polyangiitis, started receiving treatment with oral prednisone 60mg daily. Within 3 days, he developed new weakness in the proximal legs, which was consistent with glucocorticoid related myopathy. His previous symptoms of granulomatosis with polyangiitis flared, hence the dose of prednisone was tapered to 40mg daily. Additionally, he also received treatment with IV methylprednisolone 500mg for three days. Subsequently, he developed glucocorticoid induced hyperglycaemia. The man was treated with cyclophosphamide [outcomes not stated]. Author comment: "Within 3 days, new weakness developed in the proximal legs; glucocorticoid related myopathy was considered". "[G]lucocorticoid-induced hyperglycemia". Palamara K, et al. Case 32-2017: A 64-year-old man with dyspnea, wheezing, headache, cough, and night sweats. New England Journal of Medicine 377: 1569-1578, No. 16, 19 Oct 2017. Available from: URL: NEJMcpc1703513 - USA 803284639 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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