Methylene blue as a suppessor of the genotoxic effect of ultraviolet radiation with a wavelength of 300–400 nm

Methylene blue as a suppessor of the genotoxic effect of ultraviolet radiation with a wavelength... Ultraviolet radiation with a wavelength of 300–400 nm is characteristic of sunlight at the earth surface and causes DNA damage mediated by energy transfer to O2 with the transformation of the latter in the singlet state. In connection with this, scavengers of reactive oxygen species (ROSs) are potential protectors against the genotoxic effect of this kind of radiation. It was found that the methylene blue dye at doses differing by several orders of magnitude from those that are toxic for humans is able to suppress completely the SOS response induced by UV with a wavelength of 300–400 nm in Escherichia coli. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Methylene blue as a suppessor of the genotoxic effect of ultraviolet radiation with a wavelength of 300–400 nm

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2009 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795409030077
Publisher site
See Article on Publisher Site

Abstract

Ultraviolet radiation with a wavelength of 300–400 nm is characteristic of sunlight at the earth surface and causes DNA damage mediated by energy transfer to O2 with the transformation of the latter in the singlet state. In connection with this, scavengers of reactive oxygen species (ROSs) are potential protectors against the genotoxic effect of this kind of radiation. It was found that the methylene blue dye at doses differing by several orders of magnitude from those that are toxic for humans is able to suppress completely the SOS response induced by UV with a wavelength of 300–400 nm in Escherichia coli.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 20, 2009

References

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