The protein encoded by RAR-β2 (retinoic acid receptor) gene is a member of the superfamily, of nuclear receptors of retinoids which are involved in regulation of cell differentiation and proliferation. The level of RAR-β2 mRNA is downregulated in a number of cell lines derived from human epithelial tumors. Inactivation of the RAR-β2 gene is associated with methylation of its promoter region, which is observed in various carcinomas at a frequency of 30–70%. In renal and ovarian tumors, methylation at this region is poorly studied, the data being contradictory. We report a high methylation frequency in the gene promoter region in RCC (59%, 36/61) and a somewhat lower frequency in EOC (30%, 15/50). Methylation frequency in BC (46%, 26/56) is consistent with the published data. Significant correlation of methylation frequency in promoter region of RAR-β2 gene with RCC progression (P ≤ 0.005 by Fisher’s exact test) was established.
Russian Journal of Genetics – Springer Journals
Published: Aug 22, 2008
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