Methotrexate/prednisone

Methotrexate/prednisone Reactions 1704, p245 - 2 Jun 2018 Oidiodendron cerealis infection: case report A 68-year-old woman developed Oidiodendron cerealis infection while receiving immunosuppresive treatment with methotrexate and prednisone for rheumatoid arthritis [not all routes stated; dosage and time to reaction onset not stated]. The woman, who had rheumatoid arthritis, had been receiving treatment with methotrexate and oral prednisone. She presented with pain in the left hand. Flare of rheumatoid arthritis was presumed, and her oral prednisolone dose was increased by her general practitioner. After several weeks, she presented to the hospital with increased pain in the left hand and fluctuant erythematous nodules in her left arm with sporotrichoid distribution. Analysis of her history revealed recent activity of re-potting the plants. Cellulitis was suspected and bacterial and fungal swabs were collected for biopsies. The woman’s treatment was started with unspecified IV antibiotics and amphotericin. Additionally, one dose of itraconazole was also administered. Despite receiving the treatment, she developed sepsis and later died. Oidiodendron cerealis fungi was identified in culture tests from the tissue material collected from a nodule, which was also isolated on PCR. Later, the spores were also identified on a Gomori- methenamine stain. Author comment: "Immunosuppression of the patient is likely to be contributory, as invasive fungal infections, whilst difficult to diagnose, are becoming increasingly common in immunocompromised patients. Any fungus could be considered a potential cause in the immunosuppressed patient, including this rare Oidiodendron cerealis." Sideris E, et al. Case report of oidiodendron cerealis infection in the immunosuppressed patient. Australasian Journal of Dermatology 59 (Suppl. 1): 105, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323843 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Methotrexate/prednisone

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/methotrexate-prednisone-xiuAlWpjTQ
Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46888-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p245 - 2 Jun 2018 Oidiodendron cerealis infection: case report A 68-year-old woman developed Oidiodendron cerealis infection while receiving immunosuppresive treatment with methotrexate and prednisone for rheumatoid arthritis [not all routes stated; dosage and time to reaction onset not stated]. The woman, who had rheumatoid arthritis, had been receiving treatment with methotrexate and oral prednisone. She presented with pain in the left hand. Flare of rheumatoid arthritis was presumed, and her oral prednisolone dose was increased by her general practitioner. After several weeks, she presented to the hospital with increased pain in the left hand and fluctuant erythematous nodules in her left arm with sporotrichoid distribution. Analysis of her history revealed recent activity of re-potting the plants. Cellulitis was suspected and bacterial and fungal swabs were collected for biopsies. The woman’s treatment was started with unspecified IV antibiotics and amphotericin. Additionally, one dose of itraconazole was also administered. Despite receiving the treatment, she developed sepsis and later died. Oidiodendron cerealis fungi was identified in culture tests from the tissue material collected from a nodule, which was also isolated on PCR. Later, the spores were also identified on a Gomori- methenamine stain. Author comment: "Immunosuppression of the patient is likely to be contributory, as invasive fungal infections, whilst difficult to diagnose, are becoming increasingly common in immunocompromised patients. Any fungus could be considered a potential cause in the immunosuppressed patient, including this rare Oidiodendron cerealis." Sideris E, et al. Case report of oidiodendron cerealis infection in the immunosuppressed patient. Australasian Journal of Dermatology 59 (Suppl. 1): 105, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323843 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off