Methotrexate Reactions 1680, p223 - 2 Dec 2017 Macrophage activation syndrome: case report A 4-year-old girl developed macrophage activation syndrome (MAS) during treatment with methotrexate [dosage and route not stated]. The girl was diagnosed with systemic onset juvenile idiopathic arthritis and admitted. She had been receiving ibuprofen for one month prior to the admission. On admission, she was initiated on methotrexate. The following day, she developed high grade, non-remittent fever with abdominal pain, pruritus and lethargy. New onset lymphadenopathy and hepatosplenomegaly were noted. Laboratory findings demonstrated bicytopenia and low fibrinogen with elevated CRP, INR, transaminases, triglyceride and ferritin. She was diagnosed with MAS and died after four days. Author comment: "We observed methotrexate is a likely trigger of MAS in SOJIA." Roy S, et al. Methotrexate as a suspected trigger of macrophage activation syndrome in juvenile idiopathic arthritis. Journal of Nepal Paediatric Society 37: 95-97, No. 1, Jan-Apr 2017. Available from: URL: jnps.v37i1.16894 - India 803284708 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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