Methods for Contrasting Gap Time Hazard Functions: Application to Repeat Liver Transplantation

Methods for Contrasting Gap Time Hazard Functions: Application to Repeat Liver Transplantation In studies featuring a sequence of ordered events, gap times between successive events are often of interest. Despite the rich literature in this area, very few methods for comparing gap times have been developed. We propose methods for estimating a hazard ratio connecting the first and second gap times. Specifically, a two-stage procedure is developed based on estimating equations. At the first stage, a proportional hazards model is fitted for the first gap time. Weighted estimating equations are then solved at the second stage to estimate the hazard ratio between the first and second gap times. The proposed estimator has a closed form and, being analogous to a standardized mortality ratio, is easy to interpret. Large sample properties of the proposed estimators are derived, with simulation studies used to evaluate finite sample characteristics. Extension of the approach to accommodate a piecewise constant hazard ratio is considered. The proposed methods are applied to contrast repeat (second) versus primary (first) liver transplants with respect to graft failure, based on national registry data. Statistics in Biosciences Springer Journals

Methods for Contrasting Gap Time Hazard Functions: Application to Repeat Liver Transplantation

Loading next page...
Springer US
Copyright © 2016 by International Chinese Statistical Association
Statistics; Statistics for Life Sciences, Medicine, Health Sciences; Biostatistics; Theoretical Ecology/Statistics
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial