Methamphetamine-induced toxic leukoencephalopathy: clinical, radiological and autopsy findings

Methamphetamine-induced toxic leukoencephalopathy: clinical, radiological and autopsy findings Toxic leukoencephalopathy represents a process of structural alteration of the white matter. It is caused by substance abuse including drugs such as heroin, cocaine, toluene and ethanol. We reported the clinical, radiological and autopsy findings of a rare case of toxic leukoencephalopathy following chronic methamphetamine (MA) usage. A 34-year-old man with a 3-year history of MA abuse experienced progressive sluggish state, limb weakness, inability to stand and eating disorders, followed by rapid progression to coma and death. Imaging revealed hypodense CT and long T1 and T2 signals in MRI in the white matter of the bilateral periventricular and centrum semiovale regions. Histologically, white matter rarefaction, loss of myelin and axonal injury were observed. This pattern of clinical presentation, radiological manifestations and histological findings show a certain degree of particularity in toxic leukoencephalopathy. Clinically, the condition may be easily misdiagnosed as withdrawal symptoms. In suspected cases, MRI is recommended for diagnosis. The case reported here reminds clinicians and forensic pathologist of the possibility of toxic leukoencephalopathy related to MA abuse. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Forensic Science, Medicine, and Pathology" Springer Journals

Methamphetamine-induced toxic leukoencephalopathy: clinical, radiological and autopsy findings

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Pathology; Forensic Medicine; Criminology and Criminal Justice, general
ISSN
1547-769X
eISSN
1556-2891
D.O.I.
10.1007/s12024-017-9893-2
Publisher site
See Article on Publisher Site

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