J. Med. Toxicol. (2017) 13:321–328 DOI 10.1007/s13181-017-0629-1 ORIGINAL ARTICLE Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations 1 2,3 1,4 1,4 James H. Ho & Jerrold B. Leikin & Paul I. Dargan & John R. H. Archer & 1,4 5 David M. Wood & Jeffrey Brent Received: 11 May 2017 /Revised: 9 August 2017 /Accepted: 17 August 2017 /Published online: 12 September 2017 American College of Medical Toxicology 2017 Abstract Toxicology Investigators Consortium (ToxIC) Registry from Introduction There have been concerns about prosthesis fail- June 2011 to June 2015. ure and the potential for systemic toxicity due to release of Results Thirty-one cases were identified; the median (IQR) cobalt and chromium from metal-on-metal hip joint prosthe- serum cobalt concentration was 10.0 (3.8–32.8) mcg/L, and ses (MoM-HP). There is conflicting evidence on whether the median (IQR) serum chromium concentration was 6.9 there is a correlation between higher cobalt and chromium (3.7–18.7) mcg/L. Twenty-three (74.2%) had symptoms, most concentrations and systemic toxicity. commonly lethargy, hearing loss, and tinnitus. The odds ratios Methods We undertook a retrospective review of consecutive of symptomatic/asymptomatic patients for metal ion concen- patients with MoM-HP
Journal of Medical Toxicology – Springer Journals
Published: Sep 12, 2017
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