Eur J Nutr (2018) 57:119–135 https://doi.org/10.1007/s00394-016-1302-1 ORIGINAL CONTRIBUTION Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini‑pigs 1,2 1,2 4 Sergio Polakof · Didier Rémond · Annick Bernalier‑Donadille · 1,2 1,2,3 1,2 Mathieu Rambeau · Estelle Pujos‑Guillot · Blandine Comte · 1,2 1,2 Dominique Dardevet · Isabelle Savary‑Auzeloux Received: 18 March 2016 / Accepted: 16 August 2016 / Published online: 27 August 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract determining breaking points in the metabolic trajectory of Purpose In the present study, we aimed to metabolically the animals. characterize the postprandial adaptations of the major tis- Conclusions Several features confirmed the pertinence of sues involved in energy, lipids and amino acids metabo- the animal model, including increased body weight, adi- lisms in mini-pigs. posity and porcine obesity index. At the metabolic level, Method Mini-pigs were fed on high-fat–high-sucrose we observed a perturbed glucose and amino acid metabo- (HFHS) diet for 2 months and several tissues explored for lism, known to be related to the onset of the obesity. The metabolic analyses. Further, the urine metabolome was fol- urine metabolome analyses revealed several metabolic lowed over the time to picture the metabolic
European Journal of Nutrition – Springer Journals
Published: Aug 27, 2016
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