Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data

Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using... Clin Drug Investig https://doi.org/10.1007/s40261-018-0661-1 ORIGINAL RESEARCH ARTICLE Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data 1 1 1 • • Akiko Matsusaki Masayuki Kaneko Mamoru Narukawa Springer International Publishing AG, part of Springer Nature 2018 Abstract data and study duration in LOCF-based data were signifi- Background and Objective Schizophrenia treatment has cantly associated with placebo response. been shifting to resocialization by efficacious antipsychotic Conclusion Placebo response in schizophrenia clinical trials drugs. However, even some of the pivotal studies of approved published between 2007 and 2016 has not increased over new antipsychotic drugs with proven efficacy had failed due time. Differences in the healthcare environment among to high placebo response. The aim of this study was to countries were suggested to affect the evaluation of antipsy- identify the potential factors affecting placebo response by chotic drugs. Further analyses on the potential factors of meta-analysis for randomized clinical trials for antipsychotic placebo response for MMRM-based data are required. drugs using Positive and Negative Syndrome Scale (PANSS) focusing on the current methodological change in the han- dling of missing data [from last observation carried forward Key Points http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Drug Investigation Springer Journals

Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
1173-2563
eISSN
1179-1918
D.O.I.
10.1007/s40261-018-0661-1
Publisher site
See Article on Publisher Site

Abstract

Clin Drug Investig https://doi.org/10.1007/s40261-018-0661-1 ORIGINAL RESEARCH ARTICLE Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data 1 1 1 • • Akiko Matsusaki Masayuki Kaneko Mamoru Narukawa Springer International Publishing AG, part of Springer Nature 2018 Abstract data and study duration in LOCF-based data were signifi- Background and Objective Schizophrenia treatment has cantly associated with placebo response. been shifting to resocialization by efficacious antipsychotic Conclusion Placebo response in schizophrenia clinical trials drugs. However, even some of the pivotal studies of approved published between 2007 and 2016 has not increased over new antipsychotic drugs with proven efficacy had failed due time. Differences in the healthcare environment among to high placebo response. The aim of this study was to countries were suggested to affect the evaluation of antipsy- identify the potential factors affecting placebo response by chotic drugs. Further analyses on the potential factors of meta-analysis for randomized clinical trials for antipsychotic placebo response for MMRM-based data are required. drugs using Positive and Negative Syndrome Scale (PANSS) focusing on the current methodological change in the han- dling of missing data [from last observation carried forward Key Points

Journal

Clinical Drug InvestigationSpringer Journals

Published: Jun 1, 2018

References

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