Clin Drug Investig (2018) 38:751–761 https://doi.org/10.1007/s40261-018-0661-1 ORIGINAL RESEARCH ARTICLE Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data 1 1 1 • • Akiko Matsusaki Masayuki Kaneko Mamoru Narukawa Published online: 1 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results There was no correlation between publication year Background and Objective Schizophrenia treatment has and the mean change of PANSS score in the placebo arm in been shifting to resocialization by efﬁcacious antipsychotic schizophrenia studies of 10 years applying MMRM. The drugs. However, even some of the pivotal studies of approved number of countries and treatment setting in MMRM-based new antipsychotic drugs with proven efﬁcacy had failed due to data and study duration in LOCF-based data were signiﬁ- high placebo response. The aim of this study was to identify cantly associated with placebo response. the potential factors affecting placebo response by meta- Conclusion Placebo response in schizophrenia clinical trials analysis for randomized clinical trials for antipsychotic drugs published between 2007 and 2016 has not increased over using Positive and Negative Syndrome Scale (PANSS) time. Differences in the healthcare environment among focusing
Clinical Drug Investigation – Springer Journals
Published: Jun 1, 2018
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