Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data

Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using... Clin Drug Investig (2018) 38:751–761 https://doi.org/10.1007/s40261-018-0661-1 ORIGINAL RESEARCH ARTICLE Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data 1 1 1 • • Akiko Matsusaki Masayuki Kaneko Mamoru Narukawa Published online: 1 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results There was no correlation between publication year Background and Objective Schizophrenia treatment has and the mean change of PANSS score in the placebo arm in been shifting to resocialization by efficacious antipsychotic schizophrenia studies of 10 years applying MMRM. The drugs. However, even some of the pivotal studies of approved number of countries and treatment setting in MMRM-based new antipsychotic drugs with proven efficacy had failed due to data and study duration in LOCF-based data were signifi- high placebo response. The aim of this study was to identify cantly associated with placebo response. the potential factors affecting placebo response by meta- Conclusion Placebo response in schizophrenia clinical trials analysis for randomized clinical trials for antipsychotic drugs published between 2007 and 2016 has not increased over using Positive and Negative Syndrome Scale (PANSS) time. Differences in the healthcare environment among focusing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Drug Investigation Springer Journals

Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data

Loading next page...
 
/lp/springer_journal/meta-analysis-of-placebo-response-in-randomized-clinical-trials-of-7h1b0M3wvb
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
1173-2563
eISSN
1179-1918
D.O.I.
10.1007/s40261-018-0661-1
Publisher site
See Article on Publisher Site

Abstract

Clin Drug Investig (2018) 38:751–761 https://doi.org/10.1007/s40261-018-0661-1 ORIGINAL RESEARCH ARTICLE Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data 1 1 1 • • Akiko Matsusaki Masayuki Kaneko Mamoru Narukawa Published online: 1 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract Results There was no correlation between publication year Background and Objective Schizophrenia treatment has and the mean change of PANSS score in the placebo arm in been shifting to resocialization by efficacious antipsychotic schizophrenia studies of 10 years applying MMRM. The drugs. However, even some of the pivotal studies of approved number of countries and treatment setting in MMRM-based new antipsychotic drugs with proven efficacy had failed due to data and study duration in LOCF-based data were signifi- high placebo response. The aim of this study was to identify cantly associated with placebo response. the potential factors affecting placebo response by meta- Conclusion Placebo response in schizophrenia clinical trials analysis for randomized clinical trials for antipsychotic drugs published between 2007 and 2016 has not increased over using Positive and Negative Syndrome Scale (PANSS) time. Differences in the healthcare environment among focusing

Journal

Clinical Drug InvestigationSpringer Journals

Published: Jun 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off