Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer

Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis... Clin Transl Oncol (2017) 19:1147–1153 DOI 10.1007/s12094-017-1652-z RESEARCH AR TIC L E Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer 1 1 1 1 1 1 • • • • • S. Li Q. Chen H. Li Y. Wu J. Feng Y. Yan Received: 3 January 2017 / Accepted: 20 March 2017 / Published online: 3 April 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract in 21 of 28 (75.0%) patients. High expression of OCT4 Purpose Circulating tumor cells (CTCs) with epithelial-to- tended to occur in advanced patients as well as in distant mesenchymal transition (EMT) phenotypes might be rela- metastatic patients. ted to tumor progression while OCT4 expression is Conclusions The findings suggest that identification of involved in tumor metastasis and poor prognosis. But the CTCs by EMT markers as well as evaluation of OCT4 possible clinical significance of EMT phenotypes of CTCs expression status by assessment of OCT4 expression in from non-small-cell lung cancer (NSCLC) patients has still CTCs could serve as potential adjuncts for evaluating to be demonstrated. Furthermore, none has been investi- metastasis and prognosis in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Oncology Springer Journals

Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Federación de Sociedades Españolas de Oncología (FESEO)
Subject
Medicine & Public Health; Oncology
ISSN
1699-048X
eISSN
1699-3055
D.O.I.
10.1007/s12094-017-1652-z
Publisher site
See Article on Publisher Site

Abstract

Clin Transl Oncol (2017) 19:1147–1153 DOI 10.1007/s12094-017-1652-z RESEARCH AR TIC L E Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer 1 1 1 1 1 1 • • • • • S. Li Q. Chen H. Li Y. Wu J. Feng Y. Yan Received: 3 January 2017 / Accepted: 20 March 2017 / Published online: 3 April 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract in 21 of 28 (75.0%) patients. High expression of OCT4 Purpose Circulating tumor cells (CTCs) with epithelial-to- tended to occur in advanced patients as well as in distant mesenchymal transition (EMT) phenotypes might be rela- metastatic patients. ted to tumor progression while OCT4 expression is Conclusions The findings suggest that identification of involved in tumor metastasis and poor prognosis. But the CTCs by EMT markers as well as evaluation of OCT4 possible clinical significance of EMT phenotypes of CTCs expression status by assessment of OCT4 expression in from non-small-cell lung cancer (NSCLC) patients has still CTCs could serve as potential adjuncts for evaluating to be demonstrated. Furthermore, none has been investi- metastasis and prognosis in

Journal

Clinical and Translational OncologySpringer Journals

Published: Apr 3, 2017

References

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