Clin Transl Oncol (2017) 19:1147–1153 DOI 10.1007/s12094-017-1652-z RESEARCH AR TIC L E Mesenchymal circulating tumor cells (CTCs) and OCT4 mRNA expression in CTCs for prognosis prediction in patients with non-small-cell lung cancer 1 1 1 1 1 1 • • • • • S. Li Q. Chen H. Li Y. Wu J. Feng Y. Yan Received: 3 January 2017 / Accepted: 20 March 2017 / Published online: 3 April 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract in 21 of 28 (75.0%) patients. High expression of OCT4 Purpose Circulating tumor cells (CTCs) with epithelial-to- tended to occur in advanced patients as well as in distant mesenchymal transition (EMT) phenotypes might be rela- metastatic patients. ted to tumor progression while OCT4 expression is Conclusions The ﬁndings suggest that identiﬁcation of involved in tumor metastasis and poor prognosis. But the CTCs by EMT markers as well as evaluation of OCT4 possible clinical signiﬁcance of EMT phenotypes of CTCs expression status by assessment of OCT4 expression in from non-small-cell lung cancer (NSCLC) patients has still CTCs could serve as potential adjuncts for evaluating to be demonstrated. Furthermore, none has been investi- metastasis and prognosis in
Clinical and Translational Oncology – Springer Journals
Published: Apr 3, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera