Membrane Protein Folding & Lipid Interactions: Theory & Experiment

Membrane Protein Folding & Lipid Interactions: Theory & Experiment J Membrane Biol (2015) 248:369–370 DOI 10.1007/s00232-015-9819-4 EDITORIAL Membrane Protein Folding & Lipid Interactions: Theory & Experiment Alexey S. Ladokhin Published online: 24 June 2015 Springer Science+Business Media New York 2015 The notion that membrane proteins play a crucial role in assembly, was studied in the context of both lipid bilayer numerous aspects of cellular functioning (and dysfunc- [6] and translocon-like pores [7]. Several studies demon- tioning) is as popular as are the complaints that we do not strated how computational and experimental approaches know enough about their structure, assembly, and perfor- can be integrated to gain insights into the mechanism of mance within the native environment of the lipid bilayer. interfacial interactions of diphtheria toxin [8] and to vali- Both of these ideas were at the forefront of the discussion date spectroscopic tools for determining membrane pene- that occurred at a recent Telluride Science Research tration [9]. The significance of computational studies is Workshop, where a number of experimentalists and theo- further highlighted by two reviews, one specifically dedi- reticians got together to swap ideas about their research and cated to describing molecular motions associated with the to try and figure out the points of common interest, of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Membrane Protein Folding & Lipid Interactions: Theory & Experiment

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer Science+Business Media New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-015-9819-4
Publisher site
See Article on Publisher Site

Abstract

J Membrane Biol (2015) 248:369–370 DOI 10.1007/s00232-015-9819-4 EDITORIAL Membrane Protein Folding & Lipid Interactions: Theory & Experiment Alexey S. Ladokhin Published online: 24 June 2015 Springer Science+Business Media New York 2015 The notion that membrane proteins play a crucial role in assembly, was studied in the context of both lipid bilayer numerous aspects of cellular functioning (and dysfunc- [6] and translocon-like pores [7]. Several studies demon- tioning) is as popular as are the complaints that we do not strated how computational and experimental approaches know enough about their structure, assembly, and perfor- can be integrated to gain insights into the mechanism of mance within the native environment of the lipid bilayer. interfacial interactions of diphtheria toxin [8] and to vali- Both of these ideas were at the forefront of the discussion date spectroscopic tools for determining membrane pene- that occurred at a recent Telluride Science Research tration [9]. The significance of computational studies is Workshop, where a number of experimentalists and theo- further highlighted by two reviews, one specifically dedi- reticians got together to swap ideas about their research and cated to describing molecular motions associated with the to try and figure out the points of common interest, of

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jun 24, 2015

References

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