Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Saier, Can Tran, R. Barabote (2005)
TCDB: the Transporter Classification Database for membrane transport protein analyses and informationNucleic Acids Research, 34
M. Yen, Jonathan Chen, J. Márquez, Eric Sun, M. Saier (2010)
Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters.Methods in molecular biology, 637
W. Catterall (2000)
From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium ChannelsNeuron, 26
D. Ragsdale, J. McPhee, T. Scheuer, W. Catterall (1994)
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.Science, 265 5179
Y. Zhai, M. Saier (2001)
A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins.Journal of molecular microbiology and biotechnology, 3 2
O. Hamill, A. Marty, E. Neher, B. Sakmann, F. Sigworth (1981)
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesPflügers Archiv, 391
Can Tran, M. Saier (2004)
The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily.Microbiology, 150 Pt 1
(2001)
Classical mechanisms of block
A. Leffler, A. Reiprich, D. Mohapatra, C. Nau (2007)
Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ ChannelsJournal of Pharmacology and Experimental Therapeutics, 320
C. Nau, G. Wang (2004)
Interactions of Local Anesthetics with Voltage-gated Na+ ChannelsThe Journal of Membrane Biology, 201
Jens Kaiser, Douglas Rees (2008)
Structural Basis of Trans-Inhibition in a Molybdate / Tungstate ABC Transporter
M. Dayhoff, W. Barker, L. Hunt (1983)
Establishing homologies in protein sequences.Methods in enzymology, 91
R. Gutknecht, Rudolf Beutler, L. Garcia-Alles, U. Baumann, B. Erni (2001)
The dihydroxyacetone kinase of Escherichia coli utilizes a phosphoprotein instead of ATP as phosphoryl donorThe EMBO Journal, 20
Y. Zhai, M. Saier (2001)
A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence.Journal of molecular microbiology and biotechnology, 3 4
B. Hille (2001)
Ionic channels of excitable membranes
N. Kadaba, J. Kaiser, Eric Johnson, Allen Lee, D. Rees (2008)
The High-Affinity E. coli Methionine ABC Transporter: Structure and Allosteric RegulationScience, 321
S. Luo, G. Perry, S. Levinson, M. Henry (2008)
Nav1.7 expression is increased in painful human dental pulpMolecular Pain, 4
M. Yen, Jeehye Choi, M. Jr. (2009)
Bioinformatic Analyses of Transmembrane Transport: Novel Software for Deducing Protein Phylogeny, Topology, and EvolutionJournal of Molecular Microbiology and Biotechnology, 17
Juan Zhao, Rahima Ziane, A. Chatelier, M. O'leary, M. Chahine (2007)
Lidocaine promotes the trafficking and functional expression of Na(v)1.8 sodium channels in mammalian cells.Journal of neurophysiology, 98 1
Sho‐Ya Wang, Jane Mitchell, E. Moczydlowski, G. Wang (2004)
Block of Inactivation-deficient Na+ Channels by Local Anesthetics in Stably Transfected Mammalian CellsThe Journal of General Physiology, 124
K. Schulze, Philip Cohen, B. Nelson (2006)
Articaine: An Effective Adjunctive Local Anesthetic for Painless Surgery at the Depth of the Muscular FasciaDermatologic Surgery, 32
R. Aldrich, D. Corey, C. Stevens (1983)
A reinterpretation of mammalian sodium channel gating based on single channel recordingNature, 306
J. Cox, F. Reimann, A. Nicholas, G. Thornton, E. Roberts, K. Springell, G. Karbani, H. Jafri, Jovaria Mannan, Y. Raashid, L. Al-Gazali, H. Hamamy, E. Valente, S. Gorman, Richard Williams, D. Mchale, J. Wood, F. Gribble, C. Woods (2006)
An SCN9A channelopathy causes congenital inability to experience painNature, 444
B. Hille (1977)
Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reactionThe Journal of General Physiology, 69
H. Pinkett, Allen Lee, P. Lum, K. Locher, D. Rees (2007)
An Inward-Facing Conformation of a Putative Metal-Chelate-Type ABC TransporterScience, 315
M. Oldham, D. Khare, F. Quiocho, A. Davidson, Jue Chen (2007)
Crystal structure of a catalytic intermediate of the maltose transporterNature, 450
Wolfgang Schwarz, Philip Palade, B. Hille (1977)
Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle.Biophysical journal, 20 3
D. Tikhonov, Iva Bruhova, B. Zhorov (2006)
Atomic determinants of state‐dependent block of sodium channels by charged local anesthetics and benzocaineFEBS Letters, 580
C. Ahern, Amy Eastwood, D. Dougherty, R. Horn (2008)
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium ChannelsCirculation Research, 102
G. Lipkind, H. Fozzard (2005)
Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium ChannelsMolecular Pharmacology, 68
Curt Warren, L. Mok, S. Gordon, A. Fouad, M. Gold (2008)
Quantification of neural protein in extirpated tooth pulp.Journal of endodontics, 34 1
J. Devereux, P. Haeberli, O. Smithies (1984)
A comprehensive set of sequence analysis programs for the VAXNucleic acids research, 12 1 Pt 1
C. Higgins (2007)
Multiple molecular mechanisms for multidrug resistance transportersNature, 446
R. Dawson, K. Locher (2006)
Structure of a bacterial multidrug ABC transporterNature, 443
Xiaofeng Zhou, Nelson Yang, Can Tran, Rikki Hvorup, M. Jr. (2003)
Web-Based Programs for the Display and Analysis of Transmembrane α-Helices in Aligned Protein SequencesJournal of Molecular Microbiology and Biotechnology, 5
Sho‐Ya Wang, Kaitlin Bonner, Corinna Russell, G. Wang (2003)
Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channels.Biophysical journal, 85 2
M. Saier, M. Yen, Keith Noto, Dorjee Tamang, C. Elkan (2008)
The Transporter Classification Database: recent advancesNucleic Acids Research, 37
Arthur Jeske, P. Blanton (2006)
Selection of local anesthetics in dentistry: clinical impression versus scientific assessment.The Journal of the American College of Dentists, 73 3
J. Thompson, T. Gibson, F. Plewniak, F. Jeanmougin, D. Higgins (1997)
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.Nucleic acids research, 25 24
Mirium Khwaja, Q. Ma, M. Saier (2005)
Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems.Research in microbiology, 156 2
C. Starmer, A. Grant, H. Strauss (1984)
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.Biophysical journal, 46 1
G. Tusnády, É. Bakos, A. Váradi, B. Sarkadi (1997)
Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transportersFEBS Letters, 402
C. Higgins (1992)
ABC transporters: from microorganisms to man.Annual review of cell biology, 8
R. Doolittle (1981)
Similar amino acid sequences: chance or common ancestry?Science, 214 4517
M. Saier, Rikki Hvorup, Ravi Barabote (2005)
Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators.Biochemical Society transactions, 33 Pt 1
Wolfgang Busch, M. Saier (2002)
The Transporter Classification (TC) System, 2002Critical Reviews in Biochemistry and Molecular Biology, 37
S. Aller, Jodie Yu, A. Ward, Yue Weng, S. Chittaboina, R. Zhuo, P. Harrell, Yenphuong Trinh, Qinghai Zhang, I. Urbatsch, G. Chang (2009)
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug BindingScience, 323
J. Reizer, A. Reizer, M. Saier (1992)
A new subfamily of bacterial ABC‐type transport systems catalyzing export of drugs and carbohydratesProtein Science, 1
Polyphyletic ABC Porters
L. Goodman, Alfred Gilhan (1941)
The Pharmacological Basis of TherapeuticsAnesthesiology, 2
W. Saurin, M. Hofnung, E. Dassa (1999)
Getting In or Out: Early Segregation Between Importers and Exporters in the Evolution of ATP-Binding Cassette (ABC) TransportersJournal of Molecular Evolution, 48
Milton Saier (1994)
Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution.Microbiological reviews, 58 1
G. Lipkind, H. Fozzard (2005)
Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Na Channels
Weizhong Li, A. Godzik (2006)
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequencesBioinformatics, 22 13
M. Leider (1985)
Goodman & Gilman's The Pharmacological Basis of Therapeutics
S. Pao, I. Paulsen, M. Saier (1998)
Major Facilitator SuperfamilyMicrobiology and Molecular Biology Reviews, 62
Rikki Hvorup, Birke Goetz, M. Niederer, K. Hollenstein, E. Perozo, K. Locher (2007)
Asymmetry in the Structure of the ABC Transporter-Binding Protein Complex BtuCD-BtuFScience, 317
U. Borchard, H. Drouin (1980)
Carticaine: action of the local anesthetic on myelinated nerve fibres.European journal of pharmacology, 62 1
Y. Zhai, M. Saier (2002)
A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins.Journal of molecular microbiology and biotechnology, 4 4
M. Saier (2000)
A Functional-Phylogenetic Classification System for Transmembrane Solute TransportersMicrobiology and Molecular Biology Reviews, 64
B. Abrahamsen, J. Zhao, C. Asante, C. Cendán, Steve Marsh, J. Martínez-Barbera, M. Nassar, A. Dickenson, J. Wood (2008)
The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory PainScience, 321
Gabriel Cota, Clay Armstrong (1989)
Sodium channel gating in clonal pituitary cells. The inactivation step is not voltage dependentThe Journal of General Physiology, 94
M. Saier (2003)
Tracing pathways of transport protein evolutionMolecular Microbiology, 48
Richard Nelson, G. Kuan, M. Saier, M. Montal (1999)
Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study.Journal of molecular microbiology and biotechnology, 1 2
A. Ward, C. Reyes, Jodie Yu, Christopher Roth, G. Chang (2007)
Flexibility in the ABC transporter MsbA: Alternating access with a twistProceedings of the National Academy of Sciences, 104
The ATP-binding cassette (ABC) superfamily consists of both importers and exporters. These transporters have, by tradition, been classified according to the ATP hydrolyzing constituents, which are monophyletic. The evolutionary origins of the transmembrane porter proteins/domains are not known. Using five distinct computer programs, we here provide convincing statistical data suggesting that the transmembrane domains of ABC exporters are polyphyletic, having arisen at least three times independently. ABC1 porters arose by intragenic triplication of a primordial two-transmembrane segment (TMS)-encoding genetic element, yielding six TMS proteins. ABC2 porters arose by intragenic duplication of a dissimilar primordial three-TMS-encoding genetic element, yielding a distinctive protein family, nonhomologous to the ABC1 proteins. ABC3 porters arose by duplication of a primordial four-TMS-encoding genetic element, yielding either eight- or 10-TMS proteins. We assign each of 48 of the 50 currently recognized families of ABC exporters to one of the three evolutionarily distinct ABC types. Currently available high-resolution structural data for ABC porters are fully consistent with our findings. These results provide guides for future structural and mechanistic studies of these important transport systems.
The Journal of Membrane Biology – Springer Journals
Published: Oct 6, 2009
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.