J. Membrane Biol. 178, 1–10 (2000) The Journal of DOI: 10.1007/s002320010009 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review A.J. Verkleij, J.A. Post Institute of Biomembranes, Department of Molecular Cell Biology, Padualaan 8, 3584CH Utrecht, The Netherlands Received: 5 July 2000/Revised: 27 July 2000 Introduction cellular (dys)functioning and signal transduction is the topic of this review. It is now 75 years ago that the lipid bilayer concept was proposed by Gorter and Grendel (1925). Since then many Phospholipid Asymmetry concepts about the organization of lipids and proteins in the membrane have been proposed, including the mile- The phospholipid classes in a biological membrane are stone of the “fluid mosaic bilayer concept” of Singer and not randomly distributed over the two membrane halves Nicolson (1972). In this concept (glyco)proteins can lat- and the concept of phospholipid asymmetry has first erally diffuse within the fluid (glyco)lipid bilayer. This been postulated by Bretscher (1972). Bretscher and also concept is appealing in its simplicity, but it is now gen- Gordesky and Marinetti (1973) based their concept of an erally accepted that there can be many domains of pro- asymmetrical transbilayer lipid distribution on experi- teins within the fluid bilayer. These include,
The Journal of Membrane Biology – Springer Journals
Published: Mar 18, 2014
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera