Membrane Phospholipid Asymmetry and Signal Transduction

Membrane Phospholipid Asymmetry and Signal Transduction J. Membrane Biol. 178, 1–10 (2000) The Journal of DOI: 10.1007/s002320010009 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review A.J. Verkleij, J.A. Post Institute of Biomembranes, Department of Molecular Cell Biology, Padualaan 8, 3584CH Utrecht, The Netherlands Received: 5 July 2000/Revised: 27 July 2000 Introduction cellular (dys)functioning and signal transduction is the topic of this review. It is now 75 years ago that the lipid bilayer concept was proposed by Gorter and Grendel (1925). Since then many Phospholipid Asymmetry concepts about the organization of lipids and proteins in the membrane have been proposed, including the mile- The phospholipid classes in a biological membrane are stone of the “fluid mosaic bilayer concept” of Singer and not randomly distributed over the two membrane halves Nicolson (1972). In this concept (glyco)proteins can lat- and the concept of phospholipid asymmetry has first erally diffuse within the fluid (glyco)lipid bilayer. This been postulated by Bretscher (1972). Bretscher and also concept is appealing in its simplicity, but it is now gen- Gordesky and Marinetti (1973) based their concept of an erally accepted that there can be many domains of pro- asymmetrical transbilayer lipid distribution on experi- teins within the fluid bilayer. These include, The Journal of Membrane Biology Springer Journals

Membrane Phospholipid Asymmetry and Signal Transduction

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Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Biochemistry, general; Human Physiology
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