Pharm Res (2018) 35: 147 https://doi.org/10.1007/s11095-018-2414-5 RESEARCH PAPER Membrane Loaded Copper Oleate PEGylated Liposome Combined with Disulfiram for Improving Synergistic Antitumor Effect In Vivo 1 1 1 1 2 3 1 1 1 1 Lingli Zhou & Liu Yang & Chulei Yang & Yi Liu & Qiuyue Chen & Wenli Pan & Qing Cai & Lifeng Luo & Lu Liu & Shan Jiang & 1 1 4 1 Haibing He & Yu Zhang & Tian Yin & Xing Tang Received: 9 March 2018 /Accepted: 19 April 2018 /Published online: 23 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . . KEY WORDS antitumor efficacy copper disulfiram ABSTRACT 2+ Purpose This work aims to create a novel Cu liposome liposome synergistic effect with excellent loading stability and develop synergistic effect with disulfiram (DSF) for the treatment of tumor. Methods Copper oleate was incorporated into the liposome ABBREVIATIONS membrane via alcohol injection method in this work. In vitro 5-Fu 5-fluorouracil release test was applied to evaluate the release profile of the AUC Area under concentration time curve liposomes. Pharmacokinetic studies were performed in rats CTR1 Copper transporter 1 and the antitumor efficacy was assessed in mice
Pharmaceutical Research – Springer Journals
Published: May 23, 2018
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