Reactions 1704, p235 - 2 Jun 2018 Toxic epidermal necrolysis: case report A 32-year-old man developed toxic epidermal necrolysis (TEN) during treatment with meloxicam for lower back pain [route and frequency not stated]. The man, who had lower back pain, started receiving meloxicam 15mg. Within hours of meloxicam administration, he developed a diffuse erythematous urticaria-like eruptions on the chest and on the trunk. Two days later, the man was treated with prednisolone. However, over the next three days, he developed blisters of the lateral tongue, oral mucosa, lips and scrotum. A dermatological review detected target-like lesions and a positive Nikolsky’s sign on the genitals, along with the urticaria-like eruptions. He was then admitted to a hospital for biopsies of his upper torso. The active blistering sites of the genital region clinically suggested SJS; however, the result of the pathological examination confirmed the diagnosis of TEN. He received treatment with IV immunoglobulin and ciclosporin for three days, to which he responded well. Author comment: "COX-2 inhibitors are well-documented as being high risk medications for Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrosis (TEN). However, there is little evidence associating meloxicam specifically with these conditions." "A pathological diagnosis of TEN was made with the provision that the active blistering sites of the genital region clinically suggest SJS." Ellsmore J, et al. A case of meloxicam induced early toxic epidermal necrosis in a 32-year-old caucasian male. Australasian Journal of Dermatology 59 (Suppl. 1): 87 (plus poster), 27 Apr 2018. Available from: URL: https://doi.org/10.1111/ ajd.17_12815 [abstract] - Australia 803323581 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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