“Megavirales”, a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses

“Megavirales”, a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses The nucleocytoplasmic large DNA viruses (NCLDVs) comprise a monophyletic group of viruses that infect animals and diverse unicellular eukaryotes. The NCLDV group includes the families Poxviridae , Asfarviridae , Iridoviridae , Ascoviridae , Phycodnaviridae , Mimiviridae and the proposed family “Marseilleviridae”. The family Mimiviridae includes the largest known viruses, with genomes in excess of one megabase, whereas the genome size in the other NCLDV families varies from 100 to 400 kilobase pairs. Most of the NCLDVs replicate in the cytoplasm of infected cells, within so-called virus factories. The NCLDVs share a common ancient origin, as demonstrated by evolutionary reconstructions that trace approximately 50 genes encoding key proteins involved in viral replication and virion formation to the last common ancestor of all these viruses. Taken together, these characteristics lead us to propose assigning an official taxonomic rank to the NCLDVs as the order “Megavirales”, in reference to the large size of the virions and genomes of these viruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

“Megavirales”, a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1768-6
Publisher site
See Article on Publisher Site

Abstract

The nucleocytoplasmic large DNA viruses (NCLDVs) comprise a monophyletic group of viruses that infect animals and diverse unicellular eukaryotes. The NCLDV group includes the families Poxviridae , Asfarviridae , Iridoviridae , Ascoviridae , Phycodnaviridae , Mimiviridae and the proposed family “Marseilleviridae”. The family Mimiviridae includes the largest known viruses, with genomes in excess of one megabase, whereas the genome size in the other NCLDV families varies from 100 to 400 kilobase pairs. Most of the NCLDVs replicate in the cytoplasm of infected cells, within so-called virus factories. The NCLDVs share a common ancient origin, as demonstrated by evolutionary reconstructions that trace approximately 50 genes encoding key proteins involved in viral replication and virion formation to the last common ancestor of all these viruses. Taken together, these characteristics lead us to propose assigning an official taxonomic rank to the NCLDVs as the order “Megavirales”, in reference to the large size of the virions and genomes of these viruses.

Journal

Archives of VirologySpringer Journals

Published: Dec 1, 2013

References

  • Evolutionary genomics of nucleo-cytoplasmic large DNA viruses
    Iyer, LM; Balaji, S; Koonin, EV; Aravind, L
  • Lausannevirus, a giant amoebal virus encoding histone doublets
    Thomas, V; Bertelli, C; Collyn, F; Casson, N; Telenti, A; Goesmann, A; Croxatto, A; Greub, G
  • External scaffold of spherical immature poxvirus particles is made of protein trimers, forming a honeycomb lattice
    Szajner, P; Weisberg, AS; Lebowitz, J; Heuser, J; Moss, B
  • Virus factories: associations of cell organelles for viral replication and morphogenesis
    Novoa, RR; Calderita, G; Arranz, R; Fontana, J; Granzow, H; Risco, C

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