Mammalian Special Report Geqome corporating Mouse Genuine Mammalian Genome 9, 345-348 (1998). © Springer-Verlag New York Inc. 1998 Allan Peter Davis, Monica J. Justice Life Sciences Division, Oak Ridge National Laboratory, P.O. Box 2009, Oak Ridge, Tennessee 37831-8080, USA Received: 8 January 1998 / Accepted: 9 January 1998 "And a mouse is miracle enough to stagger sextillions of infi- Throughout the meeting, the rhetorical question was asked, dels." So penned the American poet Walt Whitman a century ago "Do we need more mouse mutants?" The answer, apparently, is in his epic collection Leaves of Grass. Perhaps not quite a sextil- yes. Most human diseases, especially complex traits, are probably lion, but closer to 300 scientists (both infidels and the faithful) not due to null mutations in genes but rather more subtle lesions. converged upon St. Petersburg Beach, Florida, to attend the Elev- For this reason, chemical mutagenesis screens using the point mu- enth International Mouse Genome Conference (12-16 October, tagen ENU are making a huge comeback to produce better mouse 1997). And stagger they did, at the prospect and advances made in models (Davis and Justice 1998). "Give me an assay, and I'll give mouse genomics. If the future
Mammalian Genome – Springer Journals
Published: Mar 27, 2009
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