PharmacoEconomics & Outcomes News 804, p20 - 2 Jun 2018 Medication-related harm common and costly in elderly Medication-related harm (MRH) appears to be common and costly after discharge from hospital in older patients receiving polypharmacy, according to findings of a prospective UK study published in the British Journal of Clinical Pharmacology. This observational study investigated the incidence, severity, preventability and costs of MRH in 1280 older patients (≥65 years; median 82 years) after discharge from five hospitals in Southern England. Senior pharmacists followed up patients for eight weeks, and used data from hospital readmission reviews, telephone interviews with patients, and primary care records, to assess MRH and MRH-related National Health Service (NHS) utilisation. MRH was identified in 37% of patients (556 events per 1000 discharges), and most cases (81%) were serious. Overall, 52% of cases of MRH were considered to be potentially preventable; 10.7% were definitely preventable and 41.2% were possibly preventable. MRH resulted in death in four cases. The most frequent MRH events were gastrointestinal (25%) or neurological (18%). The drugs with the highest incidence of MRH events per 1000 prescriptions were opioid analgesics (399), antibacterials (189) and benzodiazepines (185). The majority of patients (79%) required healthcare during follow-up; the incidence of hospital readmission due to MRH was 78 per 1000 discharges. Estimated annual costs of post-discharge MRH to the England NHS were £396 million annually, and £243 million of this was considered to be potentially preventable. "MRH is common in older adults following hospital discharge, and results in substantial use of healthcare resources," concluded the researchers. "Increased vigilance to high-risk prescribing, and supporting appropriate use of medicines in the community might reduce this problem," they suggested. Parekh N, et al. Incidence and cost of medication harm in older adults following hospital discharge: A multicentre prospective study in the UK. British Journal of Clinical Pharmacology : 22 May 2018. Available from: URL: http:// doi.org/10.1111/bcp.13613 803324096 1173-5503/18/0804-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Jun 2018 No. 804
PharmacoEconomics & Outcomes News – Springer Journals
Published: Jun 2, 2018
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