Curr Treat Options Peds (2018) 4:221–236
Otolaryngology (EM Arjmand and D Sidell, Section Editors)
of Vascular Anomalies
Reema Padia, MD
Randall Bly, MD
Catherine Bull, BSN, MSN, ARNP
Amy E. Geddis, MD, PhD
Jonathan Perkins, DO
Division of Pediatric Otolaryngology, Department of Surgery, Seattle Children’s
Hospital, 4800 Sandpoint Way NE, Seattle, WA, 98105, USA
Department of Otolaryngology-Head and Neck Surgery, University of Washington
School of Medicine, Seattle, WA, USA
Cancer and Blood Disorders Clinic, Seattle Children’s Hospital, 4800 Sandpoint
Way NE, Seattle, WA, 98105, USA
Published online: 27 April 2018
* Springer International Publishing AG, part of Springer Nature 2018
This article is part of the Topical Collection on Otolaryngology
Keywords Infantile hemangioma
Purpose of review This chapter will summarize the most recent literature regarding the
current state of medical treatment for vascular anomalies.
Recent findings Research into the biology of these anomalies has strengthened our
understanding of each anomaly and has helped to pave the way for more tailored
treatment options involving molecular and/or genetic targets.
Summary While there is still a role for surgical intervention, medical therapies that target
the etiology of vascular anomalies may represent an alternative or adjunctive approach in
the management of these lesions.
The study of vascular anomalies has progressed signifi-
cantly through the last three decades. With more ad-
vanced diagnostic testing modalities, the characteristics
that make each anomaly unique can be better described.
Defining the specific features of each type of anomaly
has allowed in-depth research to better elucidate genetic
etiologies of these lesions. The human genome project
was completed in 2003 and that information has be-
come a valuable resource in guiding this research .
The importance of genomic medicine is incorporated