Mechanisms of Ras Protein Targeting in Mammalian Cells

Mechanisms of Ras Protein Targeting in Mammalian Cells Many physiological and oncogenic activities of the 'classical' Ras proteins (H-Ras, N-Ras and K-Ras4A and -4B) require their correct localization to the plasma membrane. Nascent Ras proteins, however, initially associate with endomembranes (the ER and in some cases the Golgi) to complete the processing of their farnesylated carboxyl-termini before they are delivered to the plasma membrane. Recent work has revealed the outlines of the intracellular pathways by which Ras proteins reach their ultimate plasma membrane destination and has indicated that these pathways differ for different Ras species. Other studies have demonstrated that mature Ras proteins can transfer between the plasma membrane and intracellular membranes, and that Ras proteins may in some cases signal from intracellular compartments. This review will describe recent progress and still-unresolved questions in these areas. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Mechanisms of Ras Protein Targeting in Mammalian Cells

Loading next page...
 
/lp/springer_journal/mechanisms-of-ras-protein-targeting-in-mammalian-cells-c68HxswuFi
Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag New York Inc.
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-002-1026-4
Publisher site
See Article on Publisher Site

Abstract

Many physiological and oncogenic activities of the 'classical' Ras proteins (H-Ras, N-Ras and K-Ras4A and -4B) require their correct localization to the plasma membrane. Nascent Ras proteins, however, initially associate with endomembranes (the ER and in some cases the Golgi) to complete the processing of their farnesylated carboxyl-termini before they are delivered to the plasma membrane. Recent work has revealed the outlines of the intracellular pathways by which Ras proteins reach their ultimate plasma membrane destination and has indicated that these pathways differ for different Ras species. Other studies have demonstrated that mature Ras proteins can transfer between the plasma membrane and intracellular membranes, and that Ras proteins may in some cases signal from intracellular compartments. This review will describe recent progress and still-unresolved questions in these areas.

Journal

The Journal of Membrane BiologySpringer Journals

Published: Dec 1, 2002

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off