Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

Measurements of the gas and particle flow within a converging-diverging nozzle for high speed... A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experiments in Fluids Springer Journals

Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery

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Publisher
Springer-Verlag
Copyright
Copyright © 2004 by Springer-Verlag
Subject
Engineering
ISSN
0723-4864
eISSN
1432-1114
D.O.I.
10.1007/s00348-004-0792-4
Publisher site
See Article on Publisher Site

Abstract

A unique system has been developed based upon the concept of accelerating pharmaceutical agents in particle form with a gas flow to attain sufficient momentum to enter the epidermis of human skin and achieve a pharmacological endpoint. This paper presents an experimental investigation of the transient gas and particle dynamics within a transonic converging-diverging nozzle prototype. The primary gas flow regimes are identified through Pitot-static pressure surveys and schlieren images with a high frame rate. The action of the gas flow-field in imparting momentum to the drug particles is investigated through schlieren imaging and time-resolved Doppler global velocimetry (DGV).

Journal

Experiments in FluidsSpringer Journals

Published: Apr 21, 2004

References

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