Mathematical and computational method for electrical analysis of biological tissues

Mathematical and computational method for electrical analysis of biological tissues This paper presents the mathematical and computational methods for the implementation of the equivalent circuit method including a thermal and electroporation calculation for the analysis of the electric response of biological tissues excited by high-voltage pulses applied through metallic electrodes. A mathematical method for evaluating the dynamic behavior of cell membrane conductance is proposed based on the electroporation asymptotic model of Neu and Krassowska. Ex vivo electroporation experiments on rat liver samples were performed, and experimental results for electrical current and surface temperature of the sample were used to adjust several parameters of the electroporation model. The adjustments provided good agreement between computational and experimental results. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computational Electronics Springer Journals

Mathematical and computational method for electrical analysis of biological tissues

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Engineering; Mathematical and Computational Engineering; Electrical Engineering; Theoretical, Mathematical and Computational Physics; Optical and Electronic Materials; Mechanical Engineering
ISSN
1569-8025
eISSN
1572-8137
D.O.I.
10.1007/s10825-017-1070-z
Publisher site
See Article on Publisher Site

Abstract

This paper presents the mathematical and computational methods for the implementation of the equivalent circuit method including a thermal and electroporation calculation for the analysis of the electric response of biological tissues excited by high-voltage pulses applied through metallic electrodes. A mathematical method for evaluating the dynamic behavior of cell membrane conductance is proposed based on the electroporation asymptotic model of Neu and Krassowska. Ex vivo electroporation experiments on rat liver samples were performed, and experimental results for electrical current and surface temperature of the sample were used to adjust several parameters of the electroporation model. The adjustments provided good agreement between computational and experimental results.

Journal

Journal of Computational ElectronicsSpringer Journals

Published: Sep 11, 2017

References

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