PharmacoEconomics & Outcomes News 792, p17 - 2 Dec 2017 Maternal streptococcal B vaccine cost effective in sub-Sahara Streptococcal B (GBS) vaccination in pregnant women appears to be cost effective for the prevention of neonatal sepsis and meningitis in low-income countries in sub-Saharan Africa, according to findings of a study published in Vaccine. A decision tree and Markov model populated with data from published literature was used to evaluate the cost effectiveness of maternal GBS immunisation for the prevention of early-onset and late-onset GBS cases and deaths in infants in Ghana, Guinea-Basseau, Nigeria and Uganda, compared with no GBS immunisation. Cost effectiveness was assessed based on two benchmarks: 0.5 GDP and GDP per capita per disability-adjusted life-year (DALY) averted. The ** assumed cost of the vaccine was $7 per dose, and the assumed vaccine efficacy rate against serotypes was 70%. It was assumed that vaccine coverage was equivalent to the proportion of pregnant women who underwent four or more antenatal visits (ANC4). Maternal GBS vaccination was estimated to prevent 30%–34% of GBS cases and deaths in Uganda and Nigeria (ANC4 48% and 51%, respectively), 42-43% of cases and deaths in Guinea-Bissau (ANC4 65%), and 55%–57% of cases and deaths in Ghana (ANC4 87%). The estimated cost of GSB vaccination was $320–$350 per DALY averted in Guinea-Bissau, Ghana and Nigeria, which was below 50% of GDP per capita in these countries. The estimated cost of per DALY averted was higher in Uganda ($573). Sensitivity analyses found that the primary drivers of cost effectiveness were the cost per dose, and the incidences of GBS cases and GBS deaths. "The vaccine would be most cost-effective in countries like Nigeria, Guinea Bissau, and Ghana, where the case fatality ratio is high, and less cost-effective in countries like Uganda, where it is relatively low, but its cost/DALY is within the range for newer vaccines already included in the routine childhood vaccination schedules of all these, and other, low-income countries," said the authors. * gross domestic product ** 2014 US dollars Russell LB, et al. Cost-effectiveness of maternal GBS immunization in low-income sub-Saharan Africa. Vaccine : 9 Nov 2017. Available from: URL: http:// doi.org/10.1016/j.vaccine.2017.07.108 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792
PharmacoEconomics & Outcomes News – Springer Journals
Published: Dec 2, 2017
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