www.nature.com/bjc ARTICLE Molecular Diagnostics MASAN: a novel staging system for prognosis of patients with oesophageal squamous cell carcinoma 1,2 1,3 4 1,5 6 1,3 1,5 6 6 Wei Liu , Jian-zhong He , Shao-hong Wang , De-kai Liu , Xue-feng Bai , Xiu-e Xu , Jian-yi Wu , Yong Jiang , Chun-quan Li , 7 1,5 1,3 Long-qi Chen , En-min Li and Li-yan Xu BACKGROUND: Oesophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers worldwide. Treatment of ESCC is in progress through accurate staging and risk assessment of patients. The emergence of potential molecular markers inspired us to construct novel staging systems with better accuracy by incorporating molecular markers. METHODS: We measured H scores of 23 protein markers and analysed eight clinical factors of 77 ESCC patients in a training set, from which we identiﬁed an optimal MASAN (MYC, ANO1, SLC52A3, Age and N-stage) signature. We constructed MASAN models using Cox PH models, and created MASAN-staging systems based on k-means clustering and minimum-distance classiﬁer. MASAN was validated in a test set (n = 77) and an independent validation set (n = 150). RESULTS: MASAN possessed high predictive accuracies and stratiﬁed ESCC patients into three prognostic
British Journal of Cancer – Springer Journals
Published: May 16, 2018
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