Maprotiline Reactions 1680, p214 - 2 Dec 2017 Mood switching: case report A man in his late 30s, developed mood switching following use of maprotiline [route not stated; age at the time of reaction onset not stated]. The man was diagnosed with depression in 1997 at the age of 29 and started receiving treatment. In 2007, he was diagnosed with bipolar disorder I. He again developed depression. He was then treated with milnacipran and mianserin. This treatment was not effective. Therefore, he started receiving maprotiline 20mg daily. Four days after his treatment with maprotiline, he experienced manic symptoms like irritability, money squandering, talkativeness, sleeplessness and an intense excitement feeling. The evaluation showed clinical global impression-BP score of 136. The man was discharged in October 2008, with a prescription of clonazepam, valproate, and lithium; however his depression returned subsequently. In January 2009, he started receiving treatment with lamotrigine. A month after starting this treatment, his depression was well controlled. No manic states or depressive moods recurred. Author comment: "Case 1 exhibited a high risk of mood switching induced by antidepressants." Muneoka K, et al. Add-on lamotrigine treatment for subsyndromal depression after manic or mixed states in bipolar disorder improved the quality of life. Case Reports in Medicine 2012: 736521, 2012. Available from: URL: http:// - Japan 803286013 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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