Mammalian Genome 8, Brief Data Reports 949 tiffed a 4.3-kb fragment present in B6 and absent in SPRET DNA. Mapping to Chromosomes 1 and 12 of mouse A second non-polymorphic fragment of lower molecular weight homologs of human protein tyrosine was also observed. Southern blot analysis with the Ptprn2 cDNA phosphatase, receptor-type, related genes probe with PstI restriction digests of genomic DNA revealed a fragment of approximately 2.3 kb in size that was present in B6 encoding pancreatic beta cell autoantigens and absent in SPRET DNA. A higher molecular weight fragment was noted in SPRET that was absent in B6. Edward H. Leiter, 1 Hideki Tsumura, 1 Previously identified homologs: The human homolog of Ptprn David V. Serreze, 1 Harold D. Chapman, 1 [gene symbol PTPRN, but described as "ICA512" (islet cell an- Daniel U. Rabin, 2 Michael S. Lan, ~ Abner L. Notkins 3 tigen 512) and "IA-2" (islet cell antigen-2) in the literature] has been mapped to Chromosome (Chr) 2q35 with human x hamster ]The Jackson Laboratory, Bar Harbor, Maine 04609-1500, USA somatic cell hybrids . The map position of the human homolog 2Bayer Research Center, West Haven, Connecticut 06516, USA of Ptprn2, described as "IA-213" in
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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