Mammalian Genome 9, 482–484 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Mapping to 1q23 of the human gene (NDUFS2) encoding the 49-kDa subunit of the mitochondrial respiratory Complex I and immunodetection of the mature protein in mitochondria 1 1 1 2 1 3 1 1 V. Procaccio, R. de Sury, P. Martinez, D. Depetris, T. Rabilloud, P. Soularue, J. Lunardi, J.-P. Issartel Laboratoire de BioEnerge ´tique Cellulaire et Pathologique, BECP/EA 2019 UJF-DBMS, CEA, 17 rue des Martyrs, 38054 Grenoble cedex 9, France Faculte´de Me ´decine de la Timone, Inserm U 406, 13385 Marseille cedex, France Ge ´ne ´thon BP 60, 91002 Evry cedex, France Received: 17 October 1997 / Accepted: 29 January 1998 Mitochondrial Complex I (or NADH-ubiquinone reductase, E.C. generating a 1605-bp sequence (Fig. 1). This cDNA contains a 220.127.116.11) is the first multimeric complex of the respiratory chain. It typical polyadenylation site (1564–1569 bp) and a polyA tail lo- catalyzes the NADH oxidation with concomitant ubiquinone re- cated 27 nucleotides downstream of this site. A 28-bp-long CA/TG duction and proton ejection out of the mitochondria. Mammalian repeat was also observed near the 38 end. We have examined this mitochondrial Complex I is an assembly
Mammalian Genome – Springer Journals
Published: Jun 1, 1998
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