Mammalian Genome 8, Brief Data Reports 297 and egam2e 1Neu show similar phenotypes although there are dif- cell line cDNA library , cloned in the EcoRI-Xhol cloning sites ferences in the degree of the PGAM activity elevation. of the pBluescript SK plasmid. Linkage analyses localized Pgam2e 1Neu to the distal region of Previously identified homologs: Human alpha-l,2-fucosyltrans- Chr 4 between markers D4Mit134 and D4Mit54 (Fig. 1). Thus, a ferase genes FUT 1 and FUT2 have been assigned to the 19q region second locus for increased PGAM activity in the mouse genome of the human genome [4,5]. has been identified. We have recovered and maintained a total of Discussion: ABH blood group antigens are carbohydrate struc- 15 mutations with altered PGAM activity in an extensive series of tures shared by glycoproteins and glycolipids, built up in stepwise mutagenesis experiments. Further studies will be undertaken to fashion by specific glycosyltransferases. H blood group antigens determine allelism with the Pgam structural locus as well as with are made by addition of fucose linked in alpha-l,2 on terminal Pgamle or Pgam2e. beta-galactosyl residues of precursors. This addition is performed by an alpha-l,2-fucosyltransferase (EC 18.104.22.168). In human, the References formation of the H structures
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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