Mammalian Genome 8, 47-49 (1997). ~enome 9 Spdnger-Verlag New York Inc. 1997 Mapping of the ribonucleotide reductase genes (Rrml, Rrm2) in the rat K. Klinga-Levan, 1 K. Helou, I R. Issa, 1 C. Szpirer, 2 J. Szpirer, 2 G. Levan 1 1Department of Genetics, G6teborg University, Lundberg Laboratory, Medicinaregatan 9C, S-413 90 G6teborg, Sweden ZDepartment of Molecular Biology, Universit6 Libre de Bruxelles, Rhode-St-Gen~se, Belgium Received: 12 May 1996 / Accepted: 21 August 1996 tion. This size variation was far from random. Four strains (BN, Ribonucleotide reductase (RR) is an important enzyme in DNA synthesis and catalyzes the reduction of ribonucleotides to deoxy- DA, SHR, LEW) always had the smallest band, four other strains ribonucleotides. The enzyme is dimeric, and the two subunits (des- (BUF, F344, WF, WKY) had bands approximately 100 bp larger, ignated M1 and M2) are encoded by separate genes in mammals. one strain (LE) had bands about 200 bp larger, and one strain In addition, several pseudogenes of the M2 subunit genes are (PVG) had bands about 400 bp larger. The tentative interpretation known in both human and mouse. In the present paper the ribo- of these findings is that the gene on RNO19 displays a
Mammalian Genome – Springer Journals
Published: Mar 23, 2009
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