Mapping of the regulatory sequence within the yellow gene enhancers of D. melanogaster, required for the long-distance enhancer–promoter interaction

Mapping of the regulatory sequence within the yellow gene enhancers of D. melanogaster, required... One of the features of transcriptional regulation in higher eukaryotes is the ability of enhancers to activate gene transcription, being at a distance, sometimes reaching several hundred kilobases away from the promoter. For several genes, it was demonstrated that cis-regulatory DNA sequences located near the core promoter sequences play an important role in the enhancer–promoter communication. In this study, we first showed that the sequence from–890 to–1620 bp relative to the yellow transcription start site, called a communicator, is required for the long-distance activation of the yellow promoter by the body and wing enhancers, as well as for their bypass of the Su(Hw)-dependent insulation. The communicator is a functional partner of a previously described regulatory element located between–69 and–100 bp in the upstream promoter region of the yellow gene. The results of this study demonstrate that specific regulatory elements in the promoter and enhancer regions may be involved in providing long-distance interactions between them. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Mapping of the regulatory sequence within the yellow gene enhancers of D. melanogaster, required for the long-distance enhancer–promoter interaction

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Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795417030085
Publisher site
See Article on Publisher Site

Abstract

One of the features of transcriptional regulation in higher eukaryotes is the ability of enhancers to activate gene transcription, being at a distance, sometimes reaching several hundred kilobases away from the promoter. For several genes, it was demonstrated that cis-regulatory DNA sequences located near the core promoter sequences play an important role in the enhancer–promoter communication. In this study, we first showed that the sequence from–890 to–1620 bp relative to the yellow transcription start site, called a communicator, is required for the long-distance activation of the yellow promoter by the body and wing enhancers, as well as for their bypass of the Su(Hw)-dependent insulation. The communicator is a functional partner of a previously described regulatory element located between–69 and–100 bp in the upstream promoter region of the yellow gene. The results of this study demonstrate that specific regulatory elements in the promoter and enhancer regions may be involved in providing long-distance interactions between them.

Journal

Russian Journal of GeneticsSpringer Journals

Published: May 18, 2017

References

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