Mammalian Genome 9, 76-77 (1998). Mammalian Genome © Springer-Verlag New York Inc. 1998 Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy George Koike, l Joseph M. Miano, l Pascale Vanvooren, 2 Masahide Shiozawa,' Claude Szpirer, Howard J. Jacob' 'Medical College of Wisconsin, Department of Physiology, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, Wisconsin 53226-0509, USA 2Ddpartement de Biologie Moleculaire, Universite Libre de Bruxelles, B-1640 Rhode-St-Genese, Belgium Received: 2 July 1997 / Accepted: 9 September 1997 SM22 is a smooth muscle cell (SMC)-specific protein originally Centromere isolated from chicken gizzard (Lees-Miller et al. 1987). The gene D8Mit6 encoding SM22 is mainly expressed in SMCs (Shanahan et al. 1993). Although SM22 is utilized as an SMC-specific marker and 15.8 is suggested to play a role in smooth muscle contraction (Kobaya- shi et al. 1994), the function of this protein remains unknown. D8Mit5 D8Mgh9 Smooth muscle contraction and proliferation have been considered 77 Fig. 1. The genetic linkage map to play a crucial role in the pathogenesis of high blood pressure. of rat Chr 8. Formal locus names D8M1t4 Interestingly, expression of the SM22 gene was also identified in include the
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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