Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy

Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac... Mammalian Genome 9, 76-77 (1998). Mammalian Genome © Springer-Verlag New York Inc. 1998 Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy George Koike, l Joseph M. Miano, l Pascale Vanvooren, 2 Masahide Shiozawa,' Claude Szpirer, Howard J. Jacob' 'Medical College of Wisconsin, Department of Physiology, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, Wisconsin 53226-0509, USA 2Ddpartement de Biologie Moleculaire, Universite Libre de Bruxelles, B-1640 Rhode-St-Genese, Belgium Received: 2 July 1997 / Accepted: 9 September 1997 SM22 is a smooth muscle cell (SMC)-specific protein originally Centromere isolated from chicken gizzard (Lees-Miller et al. 1987). The gene D8Mit6 encoding SM22 is mainly expressed in SMCs (Shanahan et al. 1993). Although SM22 is utilized as an SMC-specific marker and 15.8 is suggested to play a role in smooth muscle contraction (Kobaya- shi et al. 1994), the function of this protein remains unknown. D8Mit5 D8Mgh9 Smooth muscle contraction and proliferation have been considered 77 Fig. 1. The genetic linkage map to play a crucial role in the pathogenesis of high blood pressure. of rat Chr 8. Formal locus names D8M1t4 Interestingly, expression of the SM22 gene was also identified in include the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900684
Publisher site
See Article on Publisher Site

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