Mapping of the human Ca2+ channel β4 subunit to 2q22-23 and its expression in developing mouse

Mapping of the human Ca2+ channel β4 subunit to 2q22-23 and its expression in developing mouse Njammalian Short Communications Genome IncorP-11ng Mouee Gename © Springer-Verlag New York Inc. 1998 Mammalian Genome 9, 310-311 (1998). subunit to 2q22-23 and its Mapping of the human Ca t channel 13 4 expression in developing mouse l Fredrik Piehl, 3 Ingo Leibiger, 2 Regina Betz,' Barbara Leibiger, 2 Filip Farnebo, l Svetlana Lagercrantz, Catharina Larsson' 'Department of Molecular Medicine, Endocrine Tumor Unit, CMM L8:01, Karolinska Hospital, S-17176 Stockholm, Sweden 2Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Karolinska Hospital, S-17176 Stockholm, Sweden 'Department of Neuroscience, Karolinska Institute, S-17177 Stockholm, Sweden Received: 20 September 1997 / Accepted: 4 December 1997 Voltage-gated Cat channels are widely distributed in electrically excitable cells and involved in many cellular processes such as contraction, excitation, and secretion (Hille 1984). This multi- subunit complex consists of a,, the pore-forming unit, and several smaller subunits (a 2 , 13, y, 8). 13 subunits interact with a l subunits and have been shown to increase their functional activity and to alter their activation and inactivation kinetics. (3 subunit isoforms from four different genes have been described, named 13 1 2 , 0 3 , , 13 (3 a (Perez-Reyes and Schneider 1995). Mutations of the Ca Mammalian Genome Springer Journals

Mapping of the human Ca2+ channel β4 subunit to 2q22-23 and its expression in developing mouse

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Copyright © 1998 by Springer-Verlag New York Inc
Life Sciences; Cell Biology; Anatomy; Zoology
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