Mapping of rat Chromosome 2 markers generated from chromosome-sorted DNA

Mapping of rat Chromosome 2 markers generated from chromosome-sorted DNA A quantitative trait locus (QTL) for blood pressure has recently been mapped to a region of roughly 30 cM on rat Chromosome (Chr) 2 by linkage and by the use of congenic strains. For further fine mapping of the QTL, however, closely linked chromosome markers residing in this 30-cM region are required. In the current work, 36 new markers were generated by screening rat Chr 2-sorted DNA libraries and subsequently mapped using five F2 populations. Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker per 1.1 cM. Mammalian Genome Springer Journals

Mapping of rat Chromosome 2 markers generated from chromosome-sorted DNA

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Copyright © 1997 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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