Mapping of bovine FcγR (FCGR) genes by sperm typing allows extended use of human map information

Mapping of bovine FcγR (FCGR) genes by sperm typing allows extended use of human map information Polymorphic sites within the bovine Fcγ;RI (FCGR1), Fcγ;RII (FCGR2), and Fcγ;RIII (FCGR3) genes were used for proximal mapping of these genes to bovine Chromosome (Chr) 3 (BTA3) with paternal half-sib families from Norwegian Cattle. A fine-structure genetic map of the region was obtained by the analysis of 288 sperm cells from three bulls that were heterozygous for the loci included in the study. No recombinants were observed between FCGR2 and FCGR3 (242 sperm cells). Considering FCGR2 and FCGR3 as a single locus, a three-point linkage analysis for [FCGR2/FCGR3], FCGR1, and INRA003 was carried out. The best-supported order of the loci was found to be INRA003-FCGR1-[FCGR2/FCGR3]. Map distances in a two-point linkage analysis were 10.3 cM between [FCGR2/FCGR3] and FCGR1, and 25.5 cM between FCGR1 and 1NRA003, respectively. This linkage mapping of the bovine FCGR gene family resembles the human situation where all FCGR genes are located at Chr 1 (HSA1), at position q21-q24. Moreover, the results locate the evolutionary breakpoint between HSAlq and BTA3 within the human Iq24 region. Mammalian Genome Springer Journals

Mapping of bovine FcγR (FCGR) genes by sperm typing allows extended use of human map information

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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