Mammalian Short Communications Genome Mammalian Genome 9, 155-156 (1998). © Springer-Verlag New York Inc. 1998 Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL) Akihiko Okawa, 1 ' 2 Shiro Ikegawa, t Isao Nakamura,' Sumio Goto, 2 Hideshige Moriya, 2 Yusuke Nakamura' 'Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku. Tokyo 108, Japan 'Department of Orthopaedic Surgery, Chiba University School of Medicine, Inohana 1-8-1, Chyuo -ku, Chiba 260, Japan Received: 27 August 1997 / Accepted: 29 September 1997 Ossification of the posterior longitudinal ligament of the spine DlOMit213 n • q El El (OPLL) is an intractable disease that causes spinal-cord compres- Fig. 1. Haplotype analysis of q q D 10Mit86 n q q 38 F 2 affected progeny in a sion (Ono et al. 1977; Tsuyama 1984). Patients with OPLL fre- q q q DlOMit106 q n (twy/twy x IPI) F, intercross. quently present with severe myelopathy that occasionally leads to q q q ] q twy The markers and twy are listed tetraparesis. X-ray examination detects OPLL in 0.7-2.0% of adult D
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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