Mammalian Genome 8, 775–777 (1997). © Springer-Verlag New York Inc. 1997 Mapping and characterization of three YAC clones containing TTAGGG arrays Chao-Huang Yen, Colleen Hohman, Rosemary W. Elliott Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, 666 Elm St., Buffalo, New York 14263, USA Received: 31 January 1997 / Accepted: 5 June 1997 Mammalian telomeres are characterized by arrays of the hexamer scribed (Yen et al. 1995). y71A3B was probably a chimeric clone, TTAGGG. These arrays are 10–15 kb long on human chromo- because it hybridized to at least three different chromosome seg- somes, but can range to over 100 kb in mouse. Arrays of this ments, none of which was telomeric. No further analysis has been hexamer are also found interstitially within some chromosomes. In performed on this clone. y113A11 was mapped to Chr 1 bands C human, such an interstitial array is found on Chromosome (Chr) 2. and D, y113B7 to Chr 6 band G, and y71A1 to Chr 10 band D. Chr Analysis of the array suggests that it was formed from the telo- 6G and Chr 10D are the most distal bands on these two chromo- meres
Mammalian Genome – Springer Journals
Published: Oct 1, 1997
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