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Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in... Management of head and neck hemangiomas with oral propranolol versus oral itraconazole in conjugation with injection sodium tetra decyl sulphate. This prospective parallel clinical trial was done to check for the effectiveness of oral propranolol and oral itraconazole when used in conjugation with inj. sodium tetra decyl sulphate in treatment of head and neck haemangiomas in adult patients visiting department of ENT and head and neck surgery, VIMSAR, Burla. All the patients visiting the department with hemangioma (diagnosed clinically and by FNAC) were considered and only those who gave written informed consent and were according to our inclusion and exclusion criteria were included into the study as subjects. Dimension (length, width and hemi-circumference) of the haemangiomas were measured using disposable paper taper measures. Depth of the hemangioma was calculated based on formula and using that volume was calculated both at baseline and after 8 weeks of drug administration. Data so collected was entered into Microsoft Office Excel 2013 and statistical analysis was performed using SPSS Version 20.0. Descriptive statistics was calculated and student’s t test (paired and unpaired) was used to compare within the group (before and after) and between the groups respectively. Statistical significance was set at p ≤ 0.05. Both the groups showed statistically significant volume reduction in the lesions [p < 0.018 (propranolo + sodium tetra decyl sulphate), p < 0.025 (itraconazole + sodium tetra decyl sulphate)]. The mean decrease in volume in propranolol group was 91.92% and that in itraconazole group was 88.97%. There was no statistical difference between the final outcome of both the groups (p < 0.766) but 3 patients on propranolol had complete resolution while 1 patient on itraconazole had complete resolution of the lesion. Oral propranolol and itraconazole are both effective and safe in hemangioma in adults. The combination with inj. sodium tetra decyl sulphate has a (1) favorable impact on decreasing the overall duration of treatment. (2) Aiding in complete resolution of lesions (especially < 3 cm). Propranolol has an edge over itraconazole (more no of tumors had complete resolution). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Otolaryngology and Head and Neck Surgery Springer Journals

Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Association of Otolaryngologists of India
Subject
Medicine & Public Health; Otorhinolaryngology; Head and Neck Surgery
ISSN
0019-5421
eISSN
0973-7707
DOI
10.1007/s12070-018-1410-8
Publisher site
See Article on Publisher Site

Abstract

Management of head and neck hemangiomas with oral propranolol versus oral itraconazole in conjugation with injection sodium tetra decyl sulphate. This prospective parallel clinical trial was done to check for the effectiveness of oral propranolol and oral itraconazole when used in conjugation with inj. sodium tetra decyl sulphate in treatment of head and neck haemangiomas in adult patients visiting department of ENT and head and neck surgery, VIMSAR, Burla. All the patients visiting the department with hemangioma (diagnosed clinically and by FNAC) were considered and only those who gave written informed consent and were according to our inclusion and exclusion criteria were included into the study as subjects. Dimension (length, width and hemi-circumference) of the haemangiomas were measured using disposable paper taper measures. Depth of the hemangioma was calculated based on formula and using that volume was calculated both at baseline and after 8 weeks of drug administration. Data so collected was entered into Microsoft Office Excel 2013 and statistical analysis was performed using SPSS Version 20.0. Descriptive statistics was calculated and student’s t test (paired and unpaired) was used to compare within the group (before and after) and between the groups respectively. Statistical significance was set at p ≤ 0.05. Both the groups showed statistically significant volume reduction in the lesions [p < 0.018 (propranolo + sodium tetra decyl sulphate), p < 0.025 (itraconazole + sodium tetra decyl sulphate)]. The mean decrease in volume in propranolol group was 91.92% and that in itraconazole group was 88.97%. There was no statistical difference between the final outcome of both the groups (p < 0.766) but 3 patients on propranolol had complete resolution while 1 patient on itraconazole had complete resolution of the lesion. Oral propranolol and itraconazole are both effective and safe in hemangioma in adults. The combination with inj. sodium tetra decyl sulphate has a (1) favorable impact on decreasing the overall duration of treatment. (2) Aiding in complete resolution of lesions (especially < 3 cm). Propranolol has an edge over itraconazole (more no of tumors had complete resolution).

Journal

Indian Journal of Otolaryngology and Head and Neck Surgery – Springer Journals

Published: Jun 4, 2018

References

  • Infantile hemangiomas: how common are they? A systematic review of the medical literature
    Kilcline, C; Frieden, IJ
  • Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait
    Blei, F; Walter, J; Orlow, SJ; Marchuk, DA
  • Diagnosis and management of hemangiomas and vascular malformations of the head and neck
    Buckmiller, LM; Richter, GT; Suen, JY
  • A novel method for calculating the volume of hemangiomas
    Berk, DR; Berk, EJ; Bruckner, AL
  • Topical imiquimod in the treatment of infantile hemangiomas: a retrospective study
    Ho, NT; Lansang, P; Pope, E
  • Oral versus highdose pulse corticosteroids for problematic infantile hemangiomas:a randomized, controlled trial
    Pope, E; Krafchik, BR; Macarthur, C
  • Propranolol for severe infantile hemangiomas: follow-up report
    Sans, V; Dumas de la Roque, E; Berge, J
  • Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion
    Annabi, B; Lachambre, MP; Plouffe, K; Moumdjian, R; Béliveau, R
  • Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction
    Zhang, D; Ma, Q; Shen, S
  • Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action
    Storch, CH; Hoeger, PH
  • Oral propranolol for treatment of pediatric capillary hemangiomas
    Aletaha, M; Salour, H; Bagheri, A; Raffati, ND; Amouhashemi, N
  • Role of propranolol in hemangiomas
    Gajbhiye, V; Nath, S; Chatterjee, S; De, A; Ghosh, D; Das, SK
  • Propranolol for severe hemangiomas of infancy
    Léauté-Labrèze, C; Dumas de la Roque, E; Hubiche, T; Boralevi, F; Thambo, JB; Taïeb, A
  • Propranolol in use for treatment of complex infant hemangiomas: literature review regarding current guidelines for pre assessment and standards of care before initiation of therapy
    Fette, A
  • Review of topical beta blockers as treatment for infantile hemangiomas
    Painter, SL
  • Topical treatment for orbital capillary hemangioma in an adult using a β-blocker solution
    Ohnishi, K; Tagami, M; Morii, E; Azumi, A
  • Management of adult onset orbital hemangioma by oral propranolol: a case report
    Murthy, GJ; Goswami, M
  • Adult hepatic hemangioma: an updated review with focus on the natural course and treatment options
    Khoury, TR
  • Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis
    Mazereeuw-Hautier, J; Hoeger, PH; Benlahrech, S; Ammour, A; Broue, P; Vial, J
  • Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study
    Bertrand, J; McCuaig, C; Dubois, J; Hatami, A; Ondrejchak, S; Powell, J
  • Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study
    Abarzúa-Araya, A; Navarrete-Dechent, CP; Heusser, F; Retamal, J; Zegpi-Trueba, MS
  • Interferon α2a therapy for the life—threatening haemangioma ofinfancy
    Ezekowitz, RA; Mulliken, JB; Folkman, J
  • Treatment of massive or life-threatening hemangiomas with recombinant α2a-interferon
    Bauman, NM; Burke, DK; Smith, RH
  • Vincristine—an effective treatment of corticoid-resistant life-threatening infantile hemangiomas
    Perez, J; Pardo, J; Gomez, C
  • Oral versus high-dose pulse corticosteroids for problematic infantile hemangiomas: a randomized, controlled trial
    Pope, E; Krafchik, BR; Macarthur, C
  • Itraconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses
    Grant, SM
  • Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
    Head, SA; Shi, W; Zhao, L; Gorshkov, K; Pasunooti, K; Chen, Y; Deng, Z; Li, RJ; Shim, JS; Tan, W; Hartung, T
  • Itraconazole, a commonly used anti-fungal that inhibits Hedgehog pathway activity and cancer growth
    Kim, J; Tang, JY; Gong, R; Kim, J; Lee, JJ; Clemons, KV; Chong, CR; Chang, KS; Fereshteh, M; Gardner, D; Reya, T; Liu, JO; Epstein, EH; Stevens, DA; Beachy, PA
  • Cholesterol trafficking is required for mTOR activation in endothelial cells
    Dang, Y; Ren, YR; Liu, JO
  • The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
    Nacev, BA
  • Antiangiogenic effect of itraconazole on corneal neovascularization: a pilot experimental investigation
    Goktas, S
  • Successful treatment of oral itraconazole for infantile hemangiomas: a case series
    Ran, Y; Chen, S; Dai, Y; Kang, D; Lama, J; Ran, X; Zhuang, K
  • Treatment of oral hemangioma with 3% sodium tetradecyl sulfate: study of 20 cases
    Agarwal, S
  • Utility of sodium tetradecyl sulfate sclerotherapy from benign oral vascular lesion
    Choi, B-E; Kim, Y; Leem, D-H; Baek, J-A; Ko, SO
  • Intralesional sclerotherapy: a novel approach for the treatment of intraoral haemangiomas
    Reddy, GSP; Reddy, GV; Reddy, KSK; Priyadarshini, BS; Sree, PK
  • Sclerotherapy for the treatment of infantile hemangiomas
    Grover, C; Khurana, A; Bhattacharya, SN
  • Combination of oral corticosteroids and polidocanol sclerotherapy in the management of infantile hemangiomas
    Grover, C; Arora, P; Kedar, A; Pal, P; Lal, B
  • Combination of propranolol and sclerotherapy for treatment of infantile parotid hemangiomas
    Ma, X; Chang, M; Ouyang, T