Short Communications Incorporating Mouse Genome Mammalian Genome 10, 1168–1171 (1999). © Springer-Verlag New York Inc. 1999 The mouse silver locus encodes a single transcript truncated by the silver mutation 1 1 2 1 1 Marı ´a Martı ´nez-Esparza, Celia Jime ´nez-Cervantes, Dorothy C. Bennett, Jose ´ A. Lozano, Francisco Solano, Jose ´ C. Garcı ´a-Borro ´n Dept. of Biochemistry & Molecular Biology, School of Medicine, University of Murcia. Apt. 4021. Campus of Espinardo, 30071 Murcia, Spain Depart. of Anatomy & Developmental Biology. St George’s Hospital Medical School, London SW17 0RE, UK Received: 26 April 1999 / Accepted: 5 August 1999 In mammals, melanin synthesis occurs mainly in highly differen- and regulation are unknown. Both proteins share all other identi- tiated cells, the epidermal melanocytes, where it is restricted to fiable domains, including the cytosolic ExxPLL motif proposed as specialized organelles called melanosomes. Among the melano- a melanosomal targeting signal (Xu et al. 1997), as well as ten Ser, somal proteins known to participate in the control of melanogen- Pro, and Thr-rich tandem repeats in the melanosomal portion. esis, those encoded at the silver locus (Kwon et al. 1991) are A murine si-derived cDNA named Pmel17 was also first obviously
Mammalian Genome – Springer Journals
Published: Apr 10, 2014
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