Malignant peripheral nerve sheath tumour of median nerve - an unusual presentation: a case report

Malignant peripheral nerve sheath tumour of median nerve - an unusual presentation: a case report Malignant peripheral nerve sheath tumours (MPNST) are rare tumours, which usually occur in patients with multiple neurofibromatosis. They are common in the head and neck and trunk and only a few cases have been reported in the hand. Many of these occur in patients with von Recklinghausen’s disease and rarely as a malignant transformation of benign schwannomas. When they appear in the hand they often present with various symptoms. We encountered a patient who presented with a longstanding asymptomatic swelling of the palm. On excision the histopathology showed a high-grade malignant peripheral nerve sheath tumour, which led us to speculate that a malignant transformation had occurred in a pre-existing benign swelling. This is reported for its unusual presentation, which, to our knowledge, has never been described previously. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Malignant peripheral nerve sheath tumour of median nerve - an unusual presentation: a case report

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Medicine
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-005-0751-1
Publisher site
See Article on Publisher Site

Abstract

Malignant peripheral nerve sheath tumours (MPNST) are rare tumours, which usually occur in patients with multiple neurofibromatosis. They are common in the head and neck and trunk and only a few cases have been reported in the hand. Many of these occur in patients with von Recklinghausen’s disease and rarely as a malignant transformation of benign schwannomas. When they appear in the hand they often present with various symptoms. We encountered a patient who presented with a longstanding asymptomatic swelling of the palm. On excision the histopathology showed a high-grade malignant peripheral nerve sheath tumour, which led us to speculate that a malignant transformation had occurred in a pre-existing benign swelling. This is reported for its unusual presentation, which, to our knowledge, has never been described previously.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Aug 1, 2005

References

  • Malignant transformation in a schwannoma
    Nayler, SJ; Leiman, G; Omar, T; Cooper, K
  • Malignant nerve sheath tumour arising in a benign ancient schwannoma
    Rasbridge, SA; Browse, NL; Tighe, JR; Fletcher, CD

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